DmeEX6010526 @ dm6
Exon Skipping
Gene
FBgn0259221 | CG42321
Description
The gene ATPase 8A is referred to in FlyBase by the symbol DmelATP8A (CG42321, FBgn0259221). It is a protein_coding_gene from Dmel. It has 15 annotated transcripts and 15 polypeptides (12 unique). Gene sequence location is 2R:13414978..13439051. Its molecular function is described by: ATP binding; magnesium ion binding; ATPase-coupled intramembrane lipid transporter activity. It is involved in the biological process described with: phospholipid translocation. 25 alleles are reported. The phenotype of these alleles manifest in: larval multidendritic class IV neuron. The phenotypic classes of alleles include: viable; partially lethal - majority die; some die during pupal stage. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 12-24 hour embryonic stages, during late pupal stages, in adult male stages.
Coordinates
chr2R:13422320-13439051:-
Coord C1 exon
chr2R:13438607-13439051
Coord A exon
chr2R:13422602-13422725
Coord C2 exon
chr2R:13422320-13422503
Length
124 bp
Sequences
Splice sites
3' ss Seq
GTTTTCATACATATTTTCAGATG
3' ss Score
7.92
5' ss Seq
TAGGTGAGT
5' ss Score
8.83
Exon sequences
Seq C1 exon
CAGCTGTAGTTAATAAAACCACAAAATGGCAAAAAGCAAAAATAAACGTCGCGACTATAACTAAAGACAAACTGACTCCTTATCGGCTTTGTTTACCGCCTTATCAACTTATATTCATATGTATGTACGTTGGTTATACACATGCATTATTCACCGTGCTTAAGTAGAATACGATCCAATCTATCAGTGCGTTAATTTATGTAGTATTTATGTTTGATGCCACAAAAGAGTTTGCCTTCTACGTGGAACTGAGCAACGGATTGTGTACAACTACAAACGGAAGCCAAACAAGGGCGGCTTTTCTTGGCTTTTCCCCGCTGCGAATCTGTCTCGGATGTTTATGTTCTGTCACCAGTTGCTCACCAGCAAGCTATGCCTTCCATTTTCCGCTTTCGTCTGCCTTTTCGCCGCAGCGAGTTACCCGAAACCGGTCTCCTGAATACCT
Seq A exon
ATGACGAGGACTTCACCTCGTCCGCTGGGTACGATGCAGATGATGGGGAGAGGCGTATCATAAACCTAAATGGGCCACAGCCCACTAAGTACGGTAATAATCGCATAACGACGGCAAAATATAG
Seq C2 exon
TTTCATCAGCTTTTTGCCCGCGTTCCTGTTCGAGCAATTCCGGCGTTACTCCAACTGCTTTTTCCTGCTAATTGCCATACTGCAACAAATCCCGGAGGTGTCGCCGACGGGTCGTTACACCACGCTAGTGCCACTGATGTTCATCCTTTCGGTGAGCGCCATTAAGGAGATAATCGAGGACATT
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0259221-'3-16,'3-15,14-16=AN
Average complexity
A_C2
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=0.325 C2=0.000
Domain overlap (PFAM):
C1:
NO
A:
NO
C2:
PF0012215=E1-E2_ATPase=PU(6.3=27.4)
Main Inclusion Isoform:
FBpp0289037
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
FBpp0289032, FBpp0289033, FBpp0289034, FBpp0289035, FBpp0289036, FBpp0289038, FBpp0289039, FBpp0289040, FBpp0289041, FBpp0289042, FBpp0289043, FBpp0292219, FBpp0297637
Other Skipping Isoforms:
NA
Associated events
Conservation
Chicken
(galGal3)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GCCTTCTACGTGGAACTGAGC
R:
CCGGAATTGCTCGAACAGGAA
Band lengths:
255-379
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)