DmeEX6010528 @ dm6

Exon Skipping

Gene

Description

The gene ATPase 8A is referred to in FlyBase by the symbol DmelATP8A (CG42321, FBgn0259221). It is a protein_coding_gene from Dmel. It has 15 annotated transcripts and 15 polypeptides (12 unique). Gene sequence location is 2R:13414978..13439051. Its molecular function is described by: ATP binding; magnesium ion binding; ATPase-coupled intramembrane lipid transporter activity. It is involved in the biological process described with: phospholipid translocation. 25 alleles are reported. The phenotype of these alleles manifest in: larval multidendritic class IV neuron. The phenotypic classes of alleles include: viable; partially lethal - majority die; some die during pupal stage. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 12-24 hour embryonic stages, during late pupal stages, in adult male stages.

Coordinates

chr2R:13420336-13422259:-

Coord C1 exon

chr2R:13422099-13422259

Coord A exon

chr2R:13421839-13422036

Coord C2 exon

chr2R:13420336-13421707

Length

198 bp

Sequences

Splice sites

3' ss Seq

CGAATCTGATGCTTCCACAGTGA

3' ss Score

5.71

5' ss Seq

GCCGTGAGT

5' ss Score

8.56

Exon sequences

Seq C1 exon

AAACGACATCGGGCGGATAATGAGATCAATCACCGATCGATAGAGCGCCTGGATAGTGGCTCGTGGTGCACAGTTCGCTGGTCGGAGTTGACGGTGGGCGATATCATCAAAGTGGGAATCAATACCTTCTTCCCCGCCGATCTGATTCTGCTGTCGTCCAG

Seq A exon

TGAACCGCAGGCCATGTGCTTCATAGAGACGGCCAATTTGGATGGTGAGACCAACCTGAAGATTCGACAGGCCCTCCCAGCCACCGCTGAACTGCTGGAGACGAAGGATCTGCAACGATTGGAGGGCAGGATCGAGTGCGAGCTGCCCAACCGGCATTTATACGAGTTTAACGGAGTGCTCAGGGAAACTGGAAAGCC

Seq C2 exon

ACCCGCTGCTTTGGGCAATGATCAGGTGCTCCAACGTGGCGCCATTCTTCGGAACACGGCATGGGTGTTCGGGATCGTGGTCTACTCCGGGCAAGAGACGAAGCTGATGAAGAACTCTACCTCGGCGCCATTGAAGCGCTCAACCGTAGACAAGCTGACCAACACCCAGATCCTCATGCTCTTCATGATCCTCATCTCATTGTGCATCATCAGCGGCTTGTGCAATCTGTTCTGGACAAGGGAACATTCGGAAACGGACTGGTACCTGGGCCTAACCGACTTCAAGACCAAGAGCCTTGGCTACAACCTGCTGACCTTCTTCATTCTGTACAACAACCTGATCCCCATCTCGCTACAGGTGACGCTTGAGCTTGTGCGTTTCCTGCAGGCCATTTTCATAAACTACGACATTGAGATGTATCACGAGGAATCAAACACGCCCGCCATGGCGCGCACCTCGAACTTGAACGAAGAGCTGGGCATGGTCAAGTATATATTCT

VastDB Features

Vast-tools module Information

Secondary ID

FBgn0259221-'16-19,'16-18,17-19=AN

Average complexity

A_S

Mappability confidence:

100%=100=100%

Protein Impact

Alternative protein isoforms (Ref)

No structure available

Features

Disorder rate (Iupred):

C1=0.000 A=0.000 C2=0.015

Domain overlap (PFAM):

C1:

PF0012215=E1-E2_ATPase=FE(19.6=100)

A:

PF0012215=E1-E2_ATPase=FE(24.4=100)

C2:

PF0012215=E1-E2_ATPase=PD(49.1=29.0),PF127102=HAD=PU(75.6=63.8)

Main Inclusion Isoform:

FBpp0289035

Main Skipping Isoform:

NA

Other Inclusion Isoforms:

FBpp0289032, FBpp0289033, FBpp0289034, FBpp0289036, FBpp0289037, FBpp0289038, FBpp0289039, FBpp0289040, FBpp0289041, FBpp0289042, FBpp0289043, FBpp0292219, FBpp0297637

Other Skipping Isoforms:

NA

Associated events

Conservation

Human

(hg38)

chr13:25541919-25542046

ALTERNATIVE

HsaEX0007067

(ATP8A2)

Human

(hg38)