DmeEX6014907 @ dm6

Exon Skipping

Gene

Description

The gene still life is referred to in FlyBase by the symbol Dmelsif (CG34418, FBgn0085447). It is a protein_coding_gene from Dmel. It has 14 annotated transcripts and 14 polypeptides (12 unique). Gene sequence location is 3L:5657913..5749599. Its molecular function is described by: Rac guanyl-nucleotide exchange factor activity. It is involved in the biological process described with 11 unique terms, many of which group under: sensory perception of light stimulus; sensory system development; activation of GTPase activity; regulation of molecular function; sensory perception. 26 alleles are reported. The phenotypes of these alleles manifest in: retinal pigment cell; eye; mesothoracic tergum; chaeta; interommatidial bristle. The phenotypic classes of alleles include: cell number defective; behavior defective; locomotor behavior defective; phenotype. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, during late pupal stages, in adult male stages.

Coordinates

chr3L:5735986-5738363:+

Coord C1 exon

chr3L:5735986-5736094

Coord A exon

chr3L:5737984-5738163

Coord C2 exon

chr3L:5738226-5738363

Length

180 bp

Sequences

Splice sites

3' ss Seq

TCTGTCCGCCATTCAAACAGACG

3' ss Score

6.81

5' ss Seq

GTGGTATGT

5' ss Score

7.64

Exon sequences

Seq C1 exon

AATGTGCTCTTTGCGATTGGCTCGGCCTTCCTGTACTACGTCAATCACTTCAAGCTCTACTCCTCGTTCTGTGCCAGTCACAGCAAGGCGCAGAAAGTCCTGCATCCGA

Seq A exon

ACGAGGGCAATCACGCCCTGCAGGAGTTCCTCGCAGCCAGGAATCCCAAGCAGCAGCATAGCAGCACCCTGGAATCGTATCTGATCAAGCCCATTCAGCGCATCCTCAAGTATCCACTGCTCCTGCAGCAGATGCGCAACCTCACAGACACCCGGGCCGATGAGCATGTGCATCTTTGTG

Seq C2 exon

AGGCACTCAAGGGCATGGAAAAGGTCGCCGAGCACATCAACGAGATGCAACGCATCCACGAGGAGTACGGTGCCATATTCGATCACCTGTTCCGGCAGCACCAGAAGTCTTGCAAACAACCCATTGATCTAAGTCCAG

VastDB Features

Vast-tools module Information

Secondary ID

FBgn0085447-'43-44,'43-43,44-44=AN

Average complexity

A_S

Mappability confidence:

100%=100=100%

Protein Impact

Alternative protein isoforms (Ref)

No structure available

Features

Disorder rate (Iupred):

C1=0.027 A=0.082 C2=0.000

Domain overlap (PFAM):

C1:

PF0062115=RhoGEF=FE(18.9=100)

A:

PF0062115=RhoGEF=FE(31.6=100)

C2:

PF0062115=RhoGEF=PD(7.4=29.8)

Main Inclusion Isoform:

FBpp0303156

Main Skipping Isoform:

NA

Other Inclusion Isoforms:

FBpp0111620, FBpp0111621, FBpp0111622, FBpp0111624, FBpp0303155, FBpp0303157, FBpp0303158, FBpp0303159, FBpp0309505, FBpp0309506, FBpp0309507, FBpp0312426

Other Skipping Isoforms:

NA

Associated events

Conservation

Human

(hg38)

chr21:31141325-31141504

HIGH PSI

HsaEX6005910

(TIAM1)

Human

(hg38)