DmeEX6023865 @ dm6
Exon Skipping
Gene
FBgn0013813 | Dhc98D
Description
The gene Dynein heavy chain at 89D is referred to in FlyBase by the symbol DmelDhc98D (CG1842, FBgn0013813). It is a protein_coding_gene from Dmel. It has 4 annotated transcripts and 4 polypeptides (3 unique). Gene sequence location is 3R:28486953..28519398. Its molecular function is described by: ATP-dependent microtubule motor activity, minus-end-directed; dynein intermediate chain binding; ATP binding; dynein light intermediate chain binding. It is involved in the biological process described with: microtubule-based movement; cilium movement. 5 alleles are reported. No phenotypic data is available. No phenotypic class data is available. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed at stages throughout the pupal period, in stages of adults of both sexes.
Coordinates
chr3R:28510442-28514663:+
Coord C1 exon
chr3R:28510442-28512747
Coord A exon
chr3R:28513417-28513488
Coord C2 exon
chr3R:28514198-28514663
Length
72 bp
Sequences
Splice sites
3' ss Seq
GTTCTCTGCCCATCGTACAGTGG
3' ss Score
4.16
5' ss Seq
CAGGCAAGT
5' ss Score
3.1
Exon sequences
Seq C1 exon
CGGCGGACATCGAGGTGCTACGAAATGGTTACCGTCCGGCTGCCAAACGTGGAGCTGTTCTTTTCTTTGCCCTATCGGACATGGCCACAGTGAATAGCATGTACCAGTATGCACTGGCCGCCTATTTGGATGTGTTCGTTTACTCCCTGCGAAAGGCTGTGCCGGATGCTAGTCTCAACAAGCGGTTGAACAACATCATCAAAACGCTTACGGAAAACGTTTACTGCTACGGGTGCACGGGCATCTTTGAACGGCATAAGCTGCTTTTCTCCTTCCAAATCGCCACTAAACTCGCCCAGCGGGACGGCATTTTGCTGCAATCCGAGCTGGACTTCTTCATTAAGGGCAGCATTGCTCTAACCAAGAGCGAACGCTCCAATCCCTGCAAATGGCTGAGTGAGAAGAGCTGGGAGGATGTGCTCAAGTTGGCCTTCGATTTCCCAGACATTTTCGGCACCTTACCAGACCACTTTGGTCGTTACCTTACCGAATGGAAAGAA
Seq A exon
TGGTTCGACTTGGAGAATCCTGAGGAGGTGCCATGTCCGGGCGACTACAACATCAAATGCAATGCATTCCAG
Seq C2 exon
AAATTAATGTTCCTGCGCTGCTTCCGCGTGGATCGCATCTTCAGGAGTATAAATCAATACATCGTCGAAACGATGGATGAGTTCTATATCATGCCGCCAGTGGTGAGCTTCTCGGCCATATACGAACAGACCTCCAGCACGATTCCCGTATGCTTTGTACTGAGTGCCGGGTCAGATCCCACAAATGATCTAATCAAACTGGCGGATACGATTGTCGGCATGTCCAACTTTTGTCACATATCTCTGGGACAGGGCCAGGAGAAGGCTGCTTTGCGACTCCTGGATGGTGCCATCAAACAGGGAATGTGGCTGATGCTGCAGAACGGACACCTGCTGATCAGGTTCGTCCGGGAACTGGAAAAGCATCTAGATCGCATAGAGAATCCACATCCGGACTTTAGGCTGTGGATAACAACAGATCCCACGCCCACATTCCCCATTGGCATTCTGCAAAAGTCGTTGAAGG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0013813-'39-38,'39-36,40-38=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.008 A=0.000 C2=0.000
Domain overlap (PFAM):
C1:
PF127772=MT=WD(100=43.7),PF127812=AAA_9=WD(100=30.0),PF0302810=Dynein_heavy=PU(6.5=6.0)
A:
PF0302810=Dynein_heavy=FE(3.2=100)
C2:
PF0302810=Dynein_heavy=FE(21.8=100)
Main Inclusion Isoform:
FBpp0290517
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
FBpp0290518, FBpp0307963
Other Skipping Isoforms:
NA
Associated events
Conservation
Primers PCR
Suggestions for RT-PCR validation
F:
CTCCAATCCCTGCAAATGGCT
R:
CTCCTGAAGATGCGATCCACG
Band lengths:
174-246
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)