DmeEX0005675 @ dm6
Exon Skipping
Gene
FBgn0038237 | Pde6
Description
The gene Phosphodiesterase 6 is referred to in FlyBase by the symbol DmelPde6 (CG8279, FBgn0038237). It is a protein_coding_gene from Dmel. It has 4 annotated transcripts and 4 polypeptides (2 unique). Gene sequence location is 3R:14513901..14558304. Its molecular function is described by: protein binding; 3',5'-cyclic-GMP phosphodiesterase activity. It is involved in the biological process described with: cGMP metabolic process; signal transduction; negative regulation of nucleobase-containing compound transport. 15 alleles are reported. No phenotypic data is available. The phenotypic classes of alleles include: fertile; viable. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, during late pupal stages, in adult male stages.
Coordinates
chr3R:14516310-14517878:-
Coord C1 exon
chr3R:14517555-14517878
Coord A exon
chr3R:14516606-14516759
Coord C2 exon
chr3R:14516310-14516469
Length
154 bp
Sequences
Splice sites
3' ss Seq
AATATTCGCTTTTTTTTTAGGCC
3' ss Score
8.84
5' ss Seq
ATTGTGAGT
5' ss Score
7.35
Exon sequences
Seq C1 exon
GTACTTTGCCGCTGGGTTTTAAGTGTTCGCAAGAATTATCGTCCTGTTAAATATCACAATTGGAGGCATGCTCTAAACGTGGCCCAAACGATGTTCGCCATGCTTAAAACTGGAAAGATGGAGCGCTTTATGACAGATCTGGAGATTCTGGGTCTGTTGGTGGCCTGTTTGTGCCATGACTTGGATCATCGTGGCACCAACAATGCATTCCAGACCAAAACGGAGTCCCCGCTGGCCATTTTGTACACCACTAGCACGATGGAGCACCATCACTTCGATCAGTGCGTAATGATTCTCAATTCGGAGGGAAATAATATATTTCAG
Seq A exon
GCCTTGTCACCTGAGGACTATCGTTCAGTCATGAAGACCGTGGAAAGCGCCATTCTGTCCACCGATCTGGCCATGTATTTCAAGAAAAGGAACGCTTTCCTAGAGTTGGTGGAAAATGGGGAATTCGATTGGCAGGGCGAGGAGAAGAAAGATT
Seq C2 exon
TGCTTTGTGGCATGATGATGACTGCTTGCGATGTGAGTGCCATTGCCAAGCCCTGGGAGGTTCAGCACAAGGTTGCCAAGTTGGTGGCCGATGAGTTCTTTGACCAAGGAGATCTCGAAAAGCTGCAGCTTAACACCCAACCAGTCGCCATGATGGACAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0038237-'14-15,'14-14,16-15
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=0.000 C2=0.037
Domain overlap (PFAM):
C1:
PF0023314=PDEase_I=PU(37.7=83.3)
A:
PF0023314=PDEase_I=FE(21.3=100)
C2:
PF0023314=PDEase_I=FE(22.2=100)
Main Inclusion Isoform:
FBpp0303081
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
FBpp0289559, FBpp0311378
Other Skipping Isoforms:
NA
Associated events
Conservation
Primers PCR
Suggestions for RT-PCR validation
F:
CTTGGATCATCGTGGCACCAA
R:
GAACTCATCGGCCACCAACTT
Band lengths:
243-397
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)