Special

DmeEX6002392 @ dm6

Exon Skipping

Gene
Description
The gene ether a go-go is referred to in FlyBase by the symbol Dmeleag (CG10952, FBgn0000535). It is a protein_coding_gene from Dmel. It has 8 annotated transcripts and 8 polypeptides (7 unique). Gene sequence location is X:14955477..15009989. Its molecular function is described by: voltage-gated cation channel activity; voltage-gated potassium channel activity; ion channel binding. It is involved in the biological process described with 11 unique terms, many of which group under: cognition; behavior; multicellular organismal process; learning or memory; transport. 31 alleles are reported. The phenotypes of these alleles manifest in: cytoplasm; organelle; nervous system; myofibril; cellular anatomical entity. The phenotypic classes of alleles include: mating defective; phenotype; sensory perception defective; behavior defective. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed during late larval stages, during early pupal stages.
Coordinates
chrX:14992720-14993766:+
Coord C1 exon
chrX:14992720-14992851
Coord A exon
chrX:14993446-14993558
Coord C2 exon
chrX:14993623-14993766
Length
113 bp
Sequences
Splice sites
3' ss Seq
GGTTAATCTATTTTTGCCAGTTT
3' ss Score
3.11
5' ss Seq
CATGTGAGT
5' ss Score
7.83
Exon sequences
Seq C1 exon
AAACCCCACTATGGCTGCTGCTACAGGTCGCACCCATACGCAACGAACGCGACCTGGTGGTGCTCTTCCTGCTGACCTTCCGGGACATCACGGCCCTCAAGCAGCCCATCGACAGCGAGGACACGAAGGGAG
Seq A exon
TTTTAGGTCTCTCGAAATTCGCCAAATTGGCAAGATCAGTGACACGGAGTCGCCAGTTCAGCGCCCATCTGCCCACGCTAAAGGATCCCACGAAGCAGTCCAATTTGGCGCAT
Seq C2 exon
ATGATGTCCTTAAGCGCGGATATCATGCCACAGTACCGACAGGAAGCTCCCAAAACGCCACCACACATACTCCTGCATTATTGTGCATTTAAAGCAATTTGGGACTGGGTGATATTGTGTTTAACATTTTATACAGCCATCATG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0000535-'9-10,'9-8,10-10=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact

ORF disruption upon sequence exclusion

No structure available
Features
Disorder rate (Iupred):
  C1=0.000 A=0.000 C2=0.000
Domain overlap (PFAM):

C1:
PF134261=PAS_9=PD(24.2=68.9)
A:
NO
C2:
PF084125=Ion_trans_N=PU(76.3=93.8)


Main Inclusion Isoform:
FBpp0073772


Main Skipping Isoform:
NA


Other Inclusion Isoforms:
FBpp0110308, FBpp0292377, FBpp0292378, FBpp0301717, FBpp0301718, FBpp0301719


Other Skipping Isoforms:
NA
Associated events
Primers PCR
Suggestions for RT-PCR validation
F:
CACTATGGCTGCTGCTACAGG
R:
ACACAATATCACCCAGTCCCA
Band lengths:
246-359
Functional annotations
There are 0 annotated functions for this event


GENOMIC CONTEXT[edit]

INCLUSION PATTERN[edit]


SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)