Special

FBgn0011259 @ dm6

Biotype
protein_coding
Gene Symbol
Sema-1a
Description
The gene Semaphorin 1a is referred to in FlyBase by the symbol DmelSema1a (CG18405, FBgn0011259). It is a protein_coding_gene from Dmel. It has 8 annotated transcripts and 8 polypeptides (6 unique). Gene sequence location is 2L:8542147..8672041. Its molecular function is described by: protein binding; chemorepellent activity; heparin binding; semaphorin receptor binding. It is involved in the biological process described with 13 unique terms, many of which group under: negative chemotaxis; negative regulation of cellular component movement; stem cell differentiation; positive regulation of cellular component movement; cell recognition. 57 alleles are reported. The phenotypes of these alleles manifest in: cellular anatomical entity; non-connected developing system; transverse nerve; adult head segment; motor neuron. The phenotypic classes of alleles include: viable; increased mortality during development; phenotype; increased mortality. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 12-18 embryonic stages.
Coordinates
chr2L:8542147-8672041:+
Assembly
dm6

GENOMIC BROWSER[edit]

EXPRESSION VALUES[edit]

SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)

EVENTS AND AS PROFILES[edit]

Associated events[edit]

Event
Type
Length
Coordinates
Strand
PSI Average
PSI Range
Annotated Functions
Alternative 3'ss
0
NA
+
50.9
94.81
0
Alternative 3'ss
18
chr2L:8662439-8662456
+
49.1
94.81
0
Alternative 5'ss
256
chr2L:8543419-8543674
+
28.15
57.06
0
Alternative 5'ss
297
chr2L:8543419-8543715
+
63.91
63.33
0
Exon Skipping
503
chr2L:8543213-8543715
+
69.14
56.91
0
Exon Skipping
63
chr2L:8664158-8664220
+
77.39
49.57
0
Exon Skipping
56
chr2L:8664375-8664430
+
3.76
17.53
0
Exon Skipping
73
chr2L:8665446-8665518
+
88.69
35.48
0
Intron Retention
828
chr2L:8543716-8544543
+
19.75
100
0
Intron Retention
969
chr2L:8661488-8662456
+
28.37
62.32
0
Intron Retention
218
chr2L:8662647-8662864
+
4.61
56.73
0
Intron Retention
2194
chr2L:8663252-8665445
+
11.96
49.61
0



Orthologous genes[edit]

Organism Assembly Gene ID Gene Name Orthology Type

Human hg38 ENSG00000092421 SEMA6A 2-to-4
Human hg38 ENSG00000137872 SEMA6D 2-to-4
Human hg38 ENSG00000143434 SEMA6C 2-to-4
Human hg38 ENSG00000167680 SEMA6B 2-to-4
Human hg19 ENSG00000092421 SEMA6A 2-to-4
Human hg19 ENSG00000137872 SEMA6D 2-to-4
Human hg19 ENSG00000143434 SEMA6C 2-to-4
Human hg19 ENSG00000167680 SEMA6B 2-to-4
Mouse mm10 ENSMUSG00000001227 Sema6b 2-to-4
Mouse mm10 ENSMUSG00000019647 Sema6a 2-to-4
Mouse mm10 ENSMUSG00000027200 Sema6d 2-to-4
Mouse mm10 ENSMUSG00000038777 Sema6c 2-to-4
Mouse mm9 ENSMUSG00000001227 Sema6b 2-to-4
Mouse mm9 ENSMUSG00000019647 Sema6a 2-to-4
Mouse mm9 ENSMUSG00000027200 Sema6d 2-to-4
Mouse mm9 ENSMUSG00000038777 Sema6c 2-to-4
Rat rn6 ENSRNOG00000004033 Sema6a 2-to-4
Rat rn6 ENSRNOG00000004812 Sema6d 2-to-4
Rat rn6 ENSRNOG00000021101 Sema6c 2-to-4
Rat rn6 ENSRNOG00000045998 Sema6b 2-to-4
Cow bosTau6 ENSBTAG00000007281 SEMA6C 2-to-4
Cow bosTau6 ENSBTAG00000016800 SEMA6D 2-to-4
Cow bosTau6 ENSBTAG00000020489 SEMA6A 2-to-4
Cow bosTau6 ENSBTAG00000031658 SEMA6B 2-to-4
Chicken galGal4 ENSGALG00000001171 SEMA6B 2-to-4
Chicken galGal4 ENSGALG00000002294 SEMA6A 2-to-4
Chicken galGal3 ENSGALG00000001171 SEMA6B 2-to-4
Chicken galGal3 ENSGALG00000002294 SEMA6A 2-to-4
Zebrafish danRer10 ENSDARG00000000189 sema6e 2-to-7
Zebrafish danRer10 ENSDARG00000002748 sema6d 2-to-7
Zebrafish danRer10 ENSDARG00000011533 sema6dl 2-to-7
Zebrafish danRer10 ENSDARG00000036626 sema6ba 2-to-7
Zebrafish danRer10 ENSDARG00000061976 sema6bb 2-to-7
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