FBgn0016059 @ dm6

Biotype

protein_coding

Gene Symbol

Sema-1b

Description

The gene Semaphorin 1b is referred to in FlyBase by the symbol DmelSema1b (CG6446, FBgn0016059). It is a protein_coding_gene from Dmel. It has 4 annotated transcripts and 4 polypeptides (1 unique). Gene sequence location is 2R:17672839..17683499. Its molecular function is described by: chemorepellent activity; semaphorin receptor binding. It is involved in the biological process described with 7 unique terms, many of which group under: positive regulation of biological process; mesenchymal cell differentiation; regulation of cell size; negative chemotaxis; regulation of biological process. 16 alleles are reported. The phenotypes of these alleles manifest in: intersegmental nerve; filamentous actin. The phenotypic classes of alleles include: locomotor behavior defective; neuroanatomy defective. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during early pupal stages.

Coordinates

chr2R:17672839-17683499:-

Assembly

dm6

GENOMIC BROWSER[edit]

EXPRESSION VALUES[edit]

SPECIAL DATASETS

Neural diversity
Neurogenesis
Neuronal activity
Splicing factor regulation (brain)
Splicing factor regulation (SL2)

EVENTS AND AS PROFILES[edit]

Associated events[edit]

Event

Type

Length

Coordinates

Strand

PSI Average

PSI Range

Annotated Functions

DmeALTD0006691-1/2

Alternative 5'ss

0

NA

-

32.41

53.31

0

DmeALTD0006691-2/2

Alternative 5'ss

84

chr2R:17679060-17679143

-

67.59

53.31

0

DmeINT0027191

Intron Retention

352

chr2R:17677920-17678271

-

4.07

51.79

0

DmeINT0027192

Intron Retention

1232

chr2R:17676594-17677825

-

5.1

64.91

0

Orthologous genes[edit]

Organism	Assembly	Gene ID	Gene Name	Orthology Type
Human	hg38	ENSG00000092421	SEMA6A	2-to-4
Human	hg38	ENSG00000137872	SEMA6D	2-to-4
Human	hg38	ENSG00000143434	SEMA6C	2-to-4
Human	hg38	ENSG00000167680	SEMA6B	2-to-4
Human	hg19	ENSG00000092421	SEMA6A	2-to-4
Human	hg19	ENSG00000137872	SEMA6D	2-to-4
Human	hg19	ENSG00000143434	SEMA6C	2-to-4
Human	hg19	ENSG00000167680	SEMA6B	2-to-4
Mouse	mm10	ENSMUSG00000001227	Sema6b	2-to-4
Mouse	mm10	ENSMUSG00000019647	Sema6a	2-to-4
Mouse	mm10	ENSMUSG00000027200	Sema6d	2-to-4
Mouse	mm10	ENSMUSG00000038777	Sema6c	2-to-4
Mouse	mm9	ENSMUSG00000001227	Sema6b	2-to-4
Mouse	mm9	ENSMUSG00000019647	Sema6a	2-to-4
Mouse	mm9	ENSMUSG00000027200	Sema6d	2-to-4
Mouse	mm9	ENSMUSG00000038777	Sema6c	2-to-4
Rat	rn6	ENSRNOG00000004033	Sema6a	2-to-4
Rat	rn6	ENSRNOG00000004812	Sema6d	2-to-4
Rat	rn6	ENSRNOG00000021101	Sema6c	2-to-4
Rat	rn6	ENSRNOG00000045998	Sema6b	2-to-4
Cow	bosTau6	ENSBTAG00000007281	SEMA6C	2-to-4
Cow	bosTau6	ENSBTAG00000016800	SEMA6D	2-to-4
Cow	bosTau6	ENSBTAG00000020489	SEMA6A	2-to-4
Cow	bosTau6	ENSBTAG00000031658	SEMA6B	2-to-4
Chicken	galGal4	ENSGALG00000001171	SEMA6B	2-to-4
Chicken	galGal4	ENSGALG00000002294	SEMA6A	2-to-4
Chicken	galGal3	ENSGALG00000001171	SEMA6B	2-to-4
Chicken	galGal3	ENSGALG00000002294	SEMA6A	2-to-4
Zebrafish	danRer10	ENSDARG00000000189	sema6e	2-to-7
Zebrafish	danRer10	ENSDARG00000002748	sema6d	2-to-7
Zebrafish	danRer10	ENSDARG00000011533	sema6dl	2-to-7
Zebrafish	danRer10	ENSDARG00000036626	sema6ba	2-to-7
Zebrafish	danRer10	ENSDARG00000061976	sema6bb	2-to-7