DmeEX0002104 @ dm6
Exon Skipping
Gene
FBgn0028497 | CG3530
Description
This gene is referred to in FlyBase by the symbol DmelCG3530 (FBgn0028497). It is a protein_coding_gene from Dmel. It has 4 annotated transcripts and 4 polypeptides (3 unique). Gene sequence location is 2R:23389009..23396680. Its molecular function is described by: metal ion binding; phosphatidylinositol-3-phosphatase activity; protein tyrosine phosphatase activity; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity. It is involved in the biological process described with: phosphatidylinositol dephosphorylation; mitotic cell cycle; regulation of autophagy. 8 alleles are reported. The phenotypes of these alleles manifest in: mesothoracic tergum; extracellular matrix; embryonic/larval fat body; trichogen cell; wing. The phenotypic classes of alleles include: planar polarity defective; visible; viable; female semi-sterile; exocytosis defective; flightless. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 and 18-24 hour embryonic stages.
Coordinates
chr2R:23391741-23396680:-
Coord C1 exon
chr2R:23396429-23396680
Coord A exon
chr2R:23393364-23393480
Coord C2 exon
chr2R:23391741-23391903
Length
117 bp
Sequences
Splice sites
3' ss Seq
CTCTGTTTTTGTTTTTGCAGGTG
3' ss Score
12.12
5' ss Seq
TGGGTAAGT
5' ss Score
10.24
Exon sequences
Seq C1 exon
TATCGACTGGAGCACATCCCTAGTTCGTACAATCGCCTCGAAGAATTTATTATTATTCGGGAATAATTACAAAAAAAATGCAATAAAAAAGCAAACACGAGTGCAGTTCTACCAAATTAACGAGGCTCCCTTGCGTGAGCTTGTGAACCGCTGGGCGAATCAGTGCACAGTGACTTTGTGGCTCGTTTTCACGTGAGGCAACAGGAAAACCCAATCAAAACGTAAACAATGGACGAAATAAAGCTCGCCAAG
Seq A exon
GTGGAAAATGTGCGGATGATAGATCGCTACAATACCAAAAATCCCACGGTTGGCACACTCTATCTAACGGCCACCCATCTGATATTCGTGGAGCCCGACAGCAACAAGGAGACCTGG
Seq C2 exon
ATCCTGCACATGCACGTGGCCAGCATTGAGAAGCTTCCCTTGAGCACGACAGGATCTCCGCTACTCATCCGCTGCAAGACCTTCCTCTCCGTAACTTTCGTCATTCCCAAGGACTCCGAGTGCCACGATGTCTACACTTCGCTGCTGAAACTCTTCCAGCCGG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0028497-'0-3,'0-2,3-3
Average complexity
C1
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=0.000 C2=0.000
Domain overlap (PFAM):
C1:
PF0289315=GRAM=PU(5.1=37.5)
A:
PF0289315=GRAM=FE(64.4=100)
C2:
PF0289315=GRAM=PD(25.4=27.3)
Main Inclusion Isoform:
FBpp0071937
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
FBpp0071938
Other Skipping Isoforms:
NA
Associated events
Conservation
Primers PCR
Suggestions for RT-PCR validation
F:
AGCAAACACGAGTGCAGTTCT
R:
GGTCTTGCAGCGGATGAGTAG
Band lengths:
244-361
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)