DmeEX0009481 @ dm6

Exon Skipping

Gene

Description

The gene short stop is referred to in FlyBase by the symbol Dmelshot (CG18076, FBgn0013733). It is a protein_coding_gene from Dmel. It has 23 annotated transcripts and 23 polypeptides (21 unique). Gene sequence location is 2R:13864237..13942110. Its molecular function is described by: microtubule binding; actin binding; protein binding; calcium ion binding; structural molecule activity. It is involved in the biological process described with 23 unique terms, many of which group under: cytoplasmic microtubule organization; wound healing; branching involved in open tracheal system development; cilium organization; regulation of microtubule polymerization or depolymerization. 114 alleles are reported. The phenotypes of these alleles manifest in: membrane-bounded organelle; endocuticle; cellular anatomical entity; stomodeal invagination late; embryonic/larval integumentary system. The phenotypic classes of alleles include: lethal; increased mortality; phenotype; increased mortality during development. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 18-24 hour embryonic stages.

Coordinates

chr2R:13882401-13901572:-

Coord C1 exon

chr2R:13901437-13901572

Coord A exon

chr2R:13900366-13900449

Coord C2 exon

chr2R:13882401-13882547

Length

84 bp

Sequences

Splice sites

3' ss Seq

TACCCCTCGAAAACCCATAGAAA

3' ss Score

2.73

5' ss Seq

AAGGTAAAA

5' ss Score

8.38

Exon sequences

Seq C1 exon

AATGCGCTCATGCGAGACGGCTATCGGGCTTATGAAGAATCTCCAGTCGAGCGTGCAAGTGGAGGAATCATGGGTGGATGGCACCACGGAGCGACTGTCTGCCATGCCCACCGCCACTTCGGCATACGAACTAGAT

Seq A exon

AAACTGCTCGGAGCTGCAATCGAACGAAAACCAAAAATCGAAAATGTCAACGTGGCTGGAGGACGACTTATACGCGAAGCTAAG

Seq C2 exon

CAAGCAGTATTCGAGAAGTTCAACATGTGCGAAGAGAATGTCAACGATCTGTTGAAATGGGTTACCACTGTGGAACAGAAAATCTCAAGTGTCGGCGGACCTCGTGAAAAGATTGATGAGTTACGCAACCAGATTAATGCCCTTAAG

VastDB Features

Vast-tools module Information

Secondary ID

FBgn0013733_MULTIEX1-1/5=C1-C2

Average complexity

ME(1-3[100=100])

Mappability confidence:

100%=100=100%

Protein Impact

Alternative protein isoforms (Ref)

No structure available

Features

Disorder rate (Iupred):

C1=0.137 A=0.000 C2=0.002

Domain overlap (PFAM):

C1:

PF0043516=Spectrin=PD(4.5=10.9)

A:

NO

C2:

PF0043516=Spectrin=PU(37.3=89.8)

Main Inclusion Isoform:

FBpp0086747

Main Skipping Isoform:

FBpp0086744

Other Inclusion Isoforms:

FBpp0086742, FBpp0086743, FBpp0086745, FBpp0271730, FBpp0271731, FBpp0271732, FBpp0271733, FBpp0271734, FBpp0290806, FBpp0290807, FBpp0290808, FBpp0293387, FBpp0293388, FBpp0293389, FBpp0293390, FBpp0293392, FBpp0293393

Other Skipping Isoforms:

FBpp0086746, FBpp0291176

Associated events