Special

DmeEX6011755 @ dm6

Exon Skipping

Gene
Description
The gene Eag-like K[+] channel is referred to in FlyBase by the symbol DmelElk (CG5076, FBgn0011589). It is a protein_coding_gene from Dmel. It has 3 annotated transcripts and 3 polypeptides (2 unique). Gene sequence location is 2R:17873939..17926695. Its molecular function is described by: voltage-gated potassium channel activity; voltage-gated cation channel activity. It is involved in the biological process described with: regulation of membrane potential; potassium ion transmembrane transport; potassium ion transport. 15 alleles are reported. No phenotypic data is available. The phenotypic classes of alleles include: partially lethal - majority die; some die during pupal stage; viable. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult male stages.
Coordinates
chr2R:17908366-17912879:+
Coord C1 exon
chr2R:17908366-17908594
Coord A exon
chr2R:17909080-17909243
Coord C2 exon
chr2R:17912678-17912879
Length
164 bp
Sequences
Splice sites
3' ss Seq
TTATTGCCGTTTTATTGCAGATA
3' ss Score
9.05
5' ss Seq
GAGGTGAGT
5' ss Score
10.03
Exon sequences
Seq C1 exon
AATTTTATGCATTCAACGGAGGCGCCGTTTCCGGAGTACAAAACCCAGTCGATAAAAAAGTCACGCTTGATTCTGCCCCATTACGGGGTGTTCAAGGGCATCTGGGATTGGGTGATTCTGGTGGCCACCTTCTACGTTGCCCTCATGGTGCCCTACAATGCCGCGTTTGCCAAAGCGGATCGGCAGACAAAGGTATCGGATGTGATTGTGGAGGCGCTCTTCATTGTAG
Seq A exon
ATATTCTGCTAAACTTCCGCACCACCTTCGTGTCGCGCAAGGGCGAGGTTGTCTCCAATTCGAAGCAGATTGCCATCAATTACCTGCGAGGATGGTTCGCCCTGGACCTTCTGGCCGCGCTGCCCTTTGATCACCTGTACGCGTCCGATTTGTACGACGGCGAG
Seq C2 exon
GATTCGCACATCCATCTTGTGAAATTGACGCGTCTCCTGCGGCTCGCTCGTCTGTTGCAAAAAATTGATCGATACTCGCAGCATACGGCCATGATACTGACATTGCTGATGTTCTCCTTCACGCTGGCCGCCCACTGGCTGGCCTGCATCTGGTATGTGATAGCGGTCAAGGAGTACGAATGGTTCCCCGAGAGCAACATCG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0011589-'10-12,'10-11,11-12=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact

ORF disruption upon sequence exclusion

No structure available
Features
Disorder rate (Iupred):
  C1=0.000 A=0.000 C2=0.000
Domain overlap (PFAM):

C1:
PF0052026=Ion_trans=PU(5.9=15.6)
A:
PF0052026=Ion_trans=FE(26.3=100)
C2:
PF0052026=Ion_trans=FE(32.7=100)


Main Inclusion Isoform:
FBpp0085981


Main Skipping Isoform:
NA


Other Inclusion Isoforms:
FBpp0309248


Other Skipping Isoforms:
NA
Associated events
Conservation
Chicken
(galGal4)
HIGH PSI
Chicken
(galGal3)
HIGH PSI
Zebrafish
(danRer10)
ALTERNATIVE
Zebrafish
(danRer10)
HIGH PSI
Zebrafish
(danRer10)
HIGH PSI
Primers PCR
Suggestions for RT-PCR validation
F:
CCCTCATGGTGCCCTACAATG
R:
CACATACCAGATGCAGGCCAG
Band lengths:
249-413
Functional annotations
There are 0 annotated functions for this event


GENOMIC CONTEXT[edit]

INCLUSION PATTERN[edit]


SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)