Special

DmeEX6015630 @ dm6

Exon Skipping

Gene
FBgn0266084 | Fhos
Description
The gene Formin homology 2 domain containing is referred to in FlyBase by the symbol DmelFhos (CG42610, FBgn0266084). It is a protein_coding_gene from Dmel. It has 10 annotated transcripts and 10 polypeptides (8 unique). Gene sequence location is 3L:8753619..8798719. Its molecular function is described by: actin filament binding. It is involved in the biological process described with 12 unique terms, many of which group under: anatomical structure morphogenesis; epithelium development; multicellular organismal process; positive regulation of cellular component movement; programmed cell death involved in cell development. 43 alleles are reported. The phenotypes of these alleles manifest in: intracellular non-membrane-bounded organelle; multicellular structure; intracellular organelle; cytoskeleton; intracellular. The phenotypic classes of alleles include: increased mortality during development; stress response defective; phenotype; fertile.
Coordinates
chr3L:8782548-8785305:+
Coord C1 exon
chr3L:8782548-8782657
Coord A exon
chr3L:8784999-8785057
Coord C2 exon
chr3L:8785121-8785305
Length
59 bp
Sequences
Splice sites
3' ss Seq
AATCTATTTGCAATCCACAGCCG
3' ss Score
5.14
5' ss Seq
TTGGTAAGT
5' ss Score
10.47
Exon sequences
Seq C1 exon
ATCGACGATGCAGCCATTCAGGTGTACAAGGATGGCGACTACGGAGCCTACTTGGATCTGGAGTCATCGCTGGCCGAACAGGCCGAGGAAATCGAGGGAGTCAACGTCAG
Seq A exon
CCGCAAAAACTCTCTGGTGGTGCGAACGCAGTTAAATGTGCGCGTACAAGCCATAATTG
Seq C2 exon
AGAAACTGCTCTCCGCACAGGGCAGTGACCTGCGGCGTGCTCTCTTCTCGCTGAAGCAGGTGTTCCAGGAGGATAAGGATCTGGTGCACGCCTTCGTGGCCCTCGGCGGCCTCAATTGCCTGGTGCGCGTGGGCAATTGTGCGGATCAAAACTATCAGAATTACATTCTGCGAGCCCTCGGTCAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0266084-'13-8,'13-7,14-8=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact

ORF disruption upon sequence exclusion

No structure available
Features
Disorder rate (Iupred):
  C1=0.054 A=0.000 C2=0.000
Domain overlap (PFAM):

C1:
NO
A:
NO
C2:
NO


Main Inclusion Isoform:
FBpp0291295


Main Skipping Isoform:
NA


Other Inclusion Isoforms:
FBpp0291296, FBpp0291739, FBpp0291740, FBpp0297586, FBpp0297587, FBpp0306020, FBpp0306021


Other Skipping Isoforms:
NA
Associated events
Primers PCR
Suggestions for RT-PCR validation
F:
CGACTACGGAGCCTACTTGGA
R:
GAACACCTGCTTCAGCGAGAA
Band lengths:
140-199
Functional annotations
There are 0 annotated functions for this event


GENOMIC CONTEXT[edit]

INCLUSION PATTERN[edit]


SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)