DmeEX6018624 @ dm6
Exon Skipping
Gene
FBgn0027951 | MTA1-like
Description
The gene Metastasis associated 1-like is referred to in FlyBase by the symbol DmelMTA1-like (CG2244, FBgn0027951). It is a protein_coding_gene from Dmel. It has 5 annotated transcripts and 5 polypeptides (4 unique). Gene sequence location is 3R:5638655..5648738. Its molecular function is described by 7 unique terms, many of which group under: binding; transcription coregulator activity; transcription regulator activity; protein binding; transcription corepressor activity. It is involved in the biological process described with: chromosome condensation; negative regulation of transcription by RNA polymerase II; heterochromatin organization involved in chromatin silencing; histone deacetylation. 17 alleles are reported. The phenotypes of these alleles manifest in: oocyte; chromosome; region; segmental subdivision of integument; cell. The phenotypic classes of alleles include: visible; partially lethal; lethal; viable; suppressor of variegation; fertile. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages.
Coordinates
chr3R:5642429-5643344:-
Coord C1 exon
chr3R:5643024-5643344
Coord A exon
chr3R:5642776-5642964
Coord C2 exon
chr3R:5642429-5642698
Length
189 bp
Sequences
Splice sites
3' ss Seq
TACTGGCGTTTACCTTTCAGTTT
3' ss Score
7.24
5' ss Seq
TTCGTAAGT
5' ss Score
9.77
Exon sequences
Seq C1 exon
GACACATTCTTCTACTGTCTGGTGTTCGATCCAAATCAAAAGACGCTGCTTGCCGACAAGGGCGAGATCCGGGTCGGCAGTCGCTACCAGTGTGATATACCCGCCAAGCTCAAGGACACCGCCACCGACGACCGCAAGCTGGAGGAACTCGAATCGCTGGTGTGGACGCCGGAGCACAGCCTGACCGACCGCAAGATAGACCAGTTCTTGGTCGTGTCACGCTCCATCGGCACCTTCGCCCGCGCCCTGGACTGCAGCAGTTCGGTGAAGCAGCCCTCGTTGCACATGTCCGCCGCGGCGGCCAGCAGGGACATCACACTG
Seq A exon
TTTCACGCAATGAACATTCTGCACAAGCACGAGTACTCTATTGAAGAGTCCATGTCGTCGCTAGTTCCTTCCACTGGGCCTGTGCTATGTCGCGATGAAATCGAGGACTGGAGCGCATCGGAGGCGAATCTTTTTGAAGAGGCGCTAGAAAAATATGGCAAAGACTTTAATGACATTCGACAAGATTTC
Seq C2 exon
CTGCCTTGGAAAACGCTGAAACAAATCATCGAGTACTACTACATGTGGAAGACCACCGATCGCTACGTGCAGCAGAAGCGAGTGAAGGCCGTCGAGGCGGAGCTGAAGCTCAAGCAGGTCTACATACCACAGTATAACAACAATGGCAAGGGGAACGGAACGTCTACGAAGGCGGGAGGTGGCATCTATAATGGAACCACAAACGGGAGCACAGATCTCTCCAGCAATGGCAAGCCATGCGAATCGTGCGGTACAACGAAATCATCACAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0027951-'20-8,'20-7,21-8=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (disopred):
C1=0.096 A=0.000 C2=0.608
Domain overlap (PFAM):
C1:
PF0142613=BAH=PD(25.7=17.8),PF0144819=ELM2=WD(100=51.4)
A:
PF0024926=Myb_DNA-binding=PU(60.9=44.4)
C2:
PF0024926=Myb_DNA-binding=PD(34.8=17.8),PF0032022=GATA=PU(26.3=11.1)
Main Inclusion Isoform:
FBpp0303347

Main Skipping Isoform:
NA
Other Inclusion Isoforms:
FBpp0078382, FBpp0078383, FBpp0288645
Other Skipping Isoforms:
NA
Associated events
Conservation
Primers PCR
Suggestions for RT-PCR validation
F:
TATACCCGCCAAGCTCAAGGA
R:
GTTTCAGCGTTTTCCAAGGCA
Band lengths:
248-437
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)