DmeEX0008592 @ dm6
Exon Skipping
Gene
FBgn0265487 | mbl
Description
The gene muscleblind is referred to in FlyBase by the symbol Dmelmbl (CG33197, FBgn0265487). It is a protein_coding_gene from Dmel. It has 19 annotated transcripts and 19 polypeptides (18 unique). Gene sequence location is 2R:17216549..17379376. Its molecular function is described by: RNA binding; metal ion binding; nucleic acid binding. It is involved in the biological process described with 9 unique terms, many of which group under: regulation of nucleobase-containing compound metabolic process; reproductive process; programmed cell death; apoptotic process; organic cyclic compound metabolic process. 93 alleles are reported. The phenotypes of these alleles manifest in: fascicle; larva; rhabdomere; visceral muscle; cytoskeleton. The phenotypic classes of alleles include: increased mortality during development; some die during embryonic stage; phenotype; courtship behavior defective.
Coordinates
chr2R:17352129-17373161:+
Coord C1 exon
chr2R:17352129-17352305
Coord A exon
chr2R:17361980-17362097
Coord C2 exon
chr2R:17373077-17373161
Length
118 bp
Sequences
Splice sites
3' ss Seq
ATCTCTTTTGCGCCAAGCAGCAA
3' ss Score
2.59
5' ss Seq
CATGTGAGT
5' ss Score
7.83
Exon sequences
Seq C1 exon
GCAACAAACCCCTATCTGACCGGCATTCCGGCCAACTCGTACAGTCCGTACTACACAACGGGACACCTGGTGCCCGCCTTGCTGGGTCCGGATCCCGTGACCTCCCAACTGGGACCCGTGGTGCCCCAAACAGTGCAGGTGGCACAGCAGAAAATACCACGTTCCGACAGATTAGAG
Seq A exon
CAATTCTCTGGCATGGTACCGTTCAAACGTCCAGCTGCCGAAAAGTCTGGCATTCCAGTTTATCAGCCCGGTGCGACCGCCTATCAGCAGCTAATGCAGCCCTACGTGCCAGTCTCAT
Seq C2 exon
TTACTGGACACCCTCCCGGTGTGCCAAGATTTTAATAGATCTATGTGCAGTCGGTTAAATTGTAGATTCGTTCATTTAACTGAAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0265487_MULTIEX2-4/6=C1-6
Average complexity
C3
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (No Ref, Alt. Stop)
No structure available
Features
Disorder rate (disopred):
C1=0.435 A=0.483 C2=0.032
Domain overlap (PFAM):
C1:
PF0064219=zf-CCCH=PU(11.1=5.1)
A:
NO
C2:
NO
Main Inclusion Isoform:
FBpp0307871
Main Skipping Isoform:
FBpp0086144
Other Inclusion Isoforms:
FBpp0086146, FBpp0297556, FBpp0297558, FBpp0297559, FBpp0297561, FBpp0301759, FBpp0301760, FBpp0302029, FBpp0307872, FBpp0307873
Other Skipping Isoforms:
NA
Associated events
Conservation
Primers PCR
Suggestions for RT-PCR validation
F:
AAACCCCTATCTGACCGGCAT
R:
CGAATCTACAATTTAACCGACTGCAC
Band lengths:
242-360
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)