DmeEX0008810 @ dm6
Exon Skipping
Gene
FBgn0004118 | nAChRbeta2
Description
The gene nicotinic Acetylcholine Receptor beta2 is referred to in FlyBase by the symbol Dmel
AChRbeta2 (CG6798, FBgn0004118). It is a protein_coding_gene from Dmel. It has 3 annotated transcripts and 3 polypeptides (2 unique). Gene sequence location is 3R:24509228..24515106. Its molecular function is described by: acetylcholine-gated cation-selective channel activity; neurotransmitter receptor activity; transmembrane signaling receptor activity. It is involved in the biological process described with 7 unique terms, many of which group under: cellular process; biological regulation; cell communication; response to stimulus; synaptic signaling. 19 alleles are reported. The phenotype of these alleles manifest in: chaeta. The phenotypic classes of alleles include: flight defective; chemical resistant; visible; lethal; viable. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period.
Coordinates
chr3R:24511484-24514012:-
Coord C1 exon
chr3R:24513880-24514012
Coord A exon
chr3R:24513695-24513822
Coord C2 exon
chr3R:24511484-24511659
Length
128 bp
Sequences
Splice sites
3' ss Seq
TGAGTATCTTCTCTTTTTAGATA
3' ss Score
9.65
5' ss Seq
AAGGTAACA
5' ss Score
8.92
Exon sequences
Seq C1 exon
ATTCCTGGCAGTAACCTAGTGCAAGTTGGCATCGATCTCACGGAATTTTATTTGTCTGTGGAATGGGACATACTTGAAGTGCCGGCTACCAAAAATGAGGAGTATTACCCCGATACACTGGAACCCTTTTCAG
Seq A exon
ATATCACATTTAAGTTGACCATGCGGCGTAAGACCTTGTTCTATACCGTTAATTTGATTGTGCCATGTGTGGCTTTAACATTCCTCACGGTGTTGGTCTTTTATTTGCCCAGCGATTCGGGCGAAAAG
Seq C2 exon
GTTACGTTATGTATTTCGATACTCGTGTCGTTGACCGTGTTTTTCCTGCTCTTGGCCGAAATTATCCCCCCAACCTCGTTGGCCGTGCCCCTGCTGGGCAAGTACCTTCTCTTTACCATGATACTCGTCTCGCTATCCGTTTGGACGACGGTCTGCGTGCTGAACATCCATTTCAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0004118_MULTIEX1-2/6=1-3
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.000 A=0.000 C2=0.000
Domain overlap (PFAM):
C1:
PF0293118=Neur_chan_LBD=FE(20.4=100)
A:
PF0293118=Neur_chan_LBD=PD(5.1=25.6),PF0293211=Neur_chan_memb=PU(10.5=55.8)
C2:
PF0293118=Neur_chan_LBD=PD(5.1=15.3),PF0293211=Neur_chan_memb=WD(100=38.9)
Main Inclusion Isoform:
FBpp0084061

Main Skipping Isoform:
NA
Other Inclusion Isoforms:
FBpp0084062
Other Skipping Isoforms:
NA
Associated events
Conservation
Chicken
(galGal3)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
AAGTTGGCATCGATCTCACGG
R:
GTCCAAACGGATAGCGAGACG
Band lengths:
257-385
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)