DmeEX0004282 @ dm6
Exon Skipping
Gene
FBgn0011589 | Elk
Description
The gene Eag-like K[+] channel is referred to in FlyBase by the symbol DmelElk (CG5076, FBgn0011589). It is a protein_coding_gene from Dmel. It has 3 annotated transcripts and 3 polypeptides (2 unique). Gene sequence location is 2R:17873939..17926695. Its molecular function is described by: voltage-gated potassium channel activity; voltage-gated cation channel activity. It is involved in the biological process described with: regulation of membrane potential; potassium ion transmembrane transport; potassium ion transport. 15 alleles are reported. No phenotypic data is available. The phenotypic classes of alleles include: partially lethal - majority die; some die during pupal stage; viable. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult male stages.
Coordinates
chr2R:17903542-17908594:+
Coord C1 exon
chr2R:17903542-17903679
Coord A exon
chr2R:17907647-17907906
Coord C2 exon
chr2R:17908366-17908594
Length
260 bp
Sequences
Splice sites
3' ss Seq
TTTTGTTGCGACTCTGTAAGTTT
3' ss Score
1.53
5' ss Seq
AATGTGAGT
5' ss Score
7.8
Exon sequences
Seq C1 exon
GTGCCCCCTTCTGGTGTTTGTTCGACATTGTGCCCATCAAGAATGAGAAGCGCGATGTGGTGCTCTTTTTGGCATCCCACAAGGACATCACGCACACCAAGATGCTGGAGATGAATGTGAACGAGGAATGTGATAGCG
Seq A exon
TTTTTGCCCTTACAGCTGCCCTTTTGGGCGCCCGGTTCCGGGCCGGCTCCAATGCCGGAATGCTCGGCCTGGGCGGACTGCCCGGTCTGGGCGGACCGGCTGCCAGTGACGGGGATACGGAGGCGGGTGAGGGCAACAATCTGGACGTTCCCGCCGGCTGCAACATGGGTCGACGGCGCAGTCGAGCGGTTCTCTACCAGCTATCCGGGCACTACAAGCCGGAAAAGGGTGGCGTGAAGACCAAGTTGAAACTGGGCAAT
Seq C2 exon
AATTTTATGCATTCAACGGAGGCGCCGTTTCCGGAGTACAAAACCCAGTCGATAAAAAAGTCACGCTTGATTCTGCCCCATTACGGGGTGTTCAAGGGCATCTGGGATTGGGTGATTCTGGTGGCCACCTTCTACGTTGCCCTCATGGTGCCCTACAATGCCGCGTTTGCCAAAGCGGATCGGCAGACAAAGGTATCGGATGTGATTGTGGAGGCGCTCTTCATTGTAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0011589-'7-10,'7-8,9-10
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.007 A=0.224 C2=0.000
Domain overlap (PFAM):
C1:
PF134261=PAS_9=PD(29.2=66.0)
A:
NO
C2:
PF0052026=Ion_trans=PU(5.9=15.6)
Main Inclusion Isoform:
FBpp0085981

Main Skipping Isoform:
FBtr0340287fB491

Other Inclusion Isoforms:
FBpp0309248
Other Skipping Isoforms:
NA
Associated events
Conservation
Primers PCR
Suggestions for RT-PCR validation
F:
AGAATGAGAAGCGCGATGTGG
R:
TCCGATACCTTTGTCTGCCGA
Band lengths:
299-559
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)