Special

DmeEX0008606 @ dm6

Exon Skipping

Gene
Description
The gene multiple edematous wings is referred to in FlyBase by the symbol Dmelmew (CG1771, FBgn0004456). It is a protein_coding_gene from Dmel. It has 7 annotated transcripts and 7 polypeptides (6 unique). Gene sequence location is X:13214409..13258490. Its molecular function is described by: protein heterodimerization activity; extracellular matrix binding; cell adhesion molecule binding. It is involved in the biological process described with 20 unique terms, many of which group under: cell adhesion; biological adhesion; cellular process; cell-cell adhesion; sensory perception of chemical stimulus. 46 alleles are reported. The phenotypes of these alleles manifest in: visual system; mitotic domain; organelle; dorsal branch primordium; endocuticle. The phenotypic classes of alleles include: lethal; increased mortality during development; phenotype; increased mortality. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period.
Coordinates
chrX:13219748-13225111:-
Coord C1 exon
chrX:13224984-13225111
Coord A exon
chrX:13220034-13220146
Coord C2 exon
chrX:13219748-13219881
Length
113 bp
Sequences
Splice sites
3' ss Seq
ATTCCCCGTTATTCGCTCAGACT
3' ss Score
5.18
5' ss Seq
AAGGTAAGC
5' ss Score
10.22
Exon sequences
Seq C1 exon
TGTTTTAGTGGGAGCTCCATTGGATCAAAATCGACAGCCGAACACCACACACTCTGGCGCCCTCTGGCGGTGTCCAATGACACAGCGTTTCGATGACTGCGAACAAGTGATCACCGATGGCAGGCGAA
Seq A exon
ACTTCGACAGCGAAATCCTTTCACCGCCCGGCAATGACGAAATCAAGGAGGATCAATGGATGGGCGTTACGGTGCGTTCGAATCCCCTACAGGCCAACGGATCCGGCGGAAAG
Seq C2 exon
GTAATCGTCTGCGCCCATCGCTATATGTACATCGTCCGAGAGAATCGTTATGGACAGGGTCTCTGCTATCTCCTAACGAACGATCTGCAATTCGAAGAGGTCCACGAGCCCTGCAAAGGACGACCTGTGCAAAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0004456-'4-10,'4-9,6-10
Average complexity
C1
Mappability confidence:
100%=100=100%
Protein Impact

ORF disruption upon sequence exclusion

No structure available
Features
Disorder rate (Iupred):
  C1=0.038 A=0.487 C2=0.156
Domain overlap (PFAM):

C1:
NO
A:
NO
C2:
NO


Main Inclusion Isoform:
FBpp0309167


Main Skipping Isoform:
NA


Other Inclusion Isoforms:
FBpp0073562, FBpp0073563, FBpp0302767, FBpp0302768, FBpp0303424


Other Skipping Isoforms:
NA
Associated events
Conservation
Chicken
(galGal3)
No conservation detected
Zebrafish
(danRer10)
HIGH PSI
Zebrafish
(danRer10)
HIGH PSI
Zebrafish
(danRer10)
HIGH PSI
Zebrafish
(danRer10)
HIGH PSI
Zebrafish
(danRer10)
Primers PCR
Suggestions for RT-PCR validation
F:
TGGGAGCTCCATTGGATCAAA
R:
TTTGCACAGGTCGTCCTTTGC
Band lengths:
253-366
Functional annotations
There are 0 annotated functions for this event


GENOMIC CONTEXT[edit]

INCLUSION PATTERN[edit]


SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)