DmeEX0008606 @ dm6
Exon Skipping
Gene
FBgn0004456 | mew
Description
The gene multiple edematous wings is referred to in FlyBase by the symbol Dmelmew (CG1771, FBgn0004456). It is a protein_coding_gene from Dmel. It has 7 annotated transcripts and 7 polypeptides (6 unique). Gene sequence location is X:13214409..13258490. Its molecular function is described by: protein heterodimerization activity; extracellular matrix binding; cell adhesion molecule binding. It is involved in the biological process described with 20 unique terms, many of which group under: cell adhesion; biological adhesion; cellular process; cell-cell adhesion; sensory perception of chemical stimulus. 46 alleles are reported. The phenotypes of these alleles manifest in: visual system; mitotic domain; organelle; dorsal branch primordium; endocuticle. The phenotypic classes of alleles include: lethal; increased mortality during development; phenotype; increased mortality. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period.
Coordinates
chrX:13219748-13225111:-
Coord C1 exon
chrX:13224984-13225111
Coord A exon
chrX:13220034-13220146
Coord C2 exon
chrX:13219748-13219881
Length
113 bp
Sequences
Splice sites
3' ss Seq
ATTCCCCGTTATTCGCTCAGACT
3' ss Score
5.18
5' ss Seq
AAGGTAAGC
5' ss Score
10.22
Exon sequences
Seq C1 exon
TGTTTTAGTGGGAGCTCCATTGGATCAAAATCGACAGCCGAACACCACACACTCTGGCGCCCTCTGGCGGTGTCCAATGACACAGCGTTTCGATGACTGCGAACAAGTGATCACCGATGGCAGGCGAA
Seq A exon
ACTTCGACAGCGAAATCCTTTCACCGCCCGGCAATGACGAAATCAAGGAGGATCAATGGATGGGCGTTACGGTGCGTTCGAATCCCCTACAGGCCAACGGATCCGGCGGAAAG
Seq C2 exon
GTAATCGTCTGCGCCCATCGCTATATGTACATCGTCCGAGAGAATCGTTATGGACAGGGTCTCTGCTATCTCCTAACGAACGATCTGCAATTCGAAGAGGTCCACGAGCCCTGCAAAGGACGACCTGTGCAAAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0004456-'4-10,'4-9,6-10
Average complexity
C1
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.038 A=0.487 C2=0.156
Domain overlap (PFAM):
C1:
NO
A:
NO
C2:
NO
Main Inclusion Isoform:
FBpp0309167

Main Skipping Isoform:
NA
Other Inclusion Isoforms:
FBpp0073562, FBpp0073563, FBpp0302767, FBpp0302768, FBpp0303424
Other Skipping Isoforms:
NA
Associated events
Conservation
Chicken
(galGal3)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
TGGGAGCTCCATTGGATCAAA
R:
TTTGCACAGGTCGTCCTTTGC
Band lengths:
253-366
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)