DmeEX6013374 @ dm6
Exon Skipping
Gene
FBgn0023081 | gek
Description
The gene genghis khan is referred to in FlyBase by the symbol Dmelgek (CG4012, FBgn0023081). It is a protein_coding_gene from Dmel. It has 2 annotated transcripts and 2 polypeptides (1 unique). Gene sequence location is 2R:24092079..24098636. Its molecular function is described by: protein kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding. It is involved in the biological process described with 6 unique terms, many of which group under: protein modification process; neuron differentiation; regulation of organelle organization; cell communication; nervous system development. 32 alleles are reported. The phenotypes of these alleles manifest in: neuron projection; cell projection; plasma membrane bounded cell projection; embryonic/larval cuticle; reproductive system. The phenotypic classes of alleles include: phenotype; increased mortality; increased mortality during development; semi-sterile. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the pupal period, in adult female stages.
Coordinates
chr2R:24093277-24097018:-
Coord C1 exon
chr2R:24094115-24097018
Coord A exon
chr2R:24093777-24094053
Coord C2 exon
chr2R:24093277-24093705
Length
277 bp
Sequences
Splice sites
3' ss Seq
GTGCATCTTCCTCATTCCAGATA
3' ss Score
9.01
5' ss Seq
ACGGTAAGC
5' ss Score
9.89
Exon sequences
Seq C1 exon
TGGTCAAGGAATCTCAGAAGAAAGTGCCCGGCAACACGGCGATCCATCAGTTCCTGGTGCGCACATTCAGTAGTCCCACAAAATGCAATCACTGCACATCGCTGATGGTGGGGCTCACACGACAAGGCGTTGTGTGCGAGATCTGCGGATTCGCCTGTCACACGATCTGCTGCCAAAAGGTGCCCACCACGTGCCCCGTGCCCATGGATCAGACGAAACGGCCGCTGGGAATCGATCCCACCAGGGGAATCGGCACGGCATACGAGGGCTACGTAAAGGTCCCCAAGTCGGGGGTGATTAAGCGAGGATGGATTCGGCAGTTCGTAGTTGTTTGCGACTTTAAGTTGTTCCTCTATGACATTTCGCCGGATCGGTGTGCATTGCCCAGCGTGAGCGTGTCCCAAGTGCTGGATATGAGGGATCCCGAGTTCTCGGTGGGTAGTGTGCGCGAAAGCGATGTCATCCATGCCGCCAAGAAAGATGTGCCATGTATTTTCAAG
Seq A exon
ATAAAAACCGCCCTTATCGATGGCGGTCTTTCGCTGAACACCCTTATGCTCGCCGACAACGAGTCGGAGAAGTCCAAGTGGGTCATTGCCCTGGGAGAACTACATCGAATATTGAAACGAAACAGCTTACCAAATACTGCTATATTTAAAGTTAACGAGATTCTGGACAATACCCTGTCTTTAATAAGAAACGCATTGTGTTCTGTCATCATATATCCAAATCAAATACTCTTGGGCACCGAAGACGGCCTGTTCTACATTAATCTGGACCAGTACG
Seq C2 exon
AGATCGCTCGTATTGGCGAAAGCAAGAAGATTCTTCAGCTATGGTACATTGAAGAGGAGCAGATCCTCGTCATTCTCTGCGGAAAGCAGCGCAACTTGCGTTTATTACCTATAAGGGCATTAGAGGCTAGTGATGTCGAGTGGATCAAGGTGGTCGAATCGAAGAACTGCATATCTGCTTGCACTGGAATAATCCGCCGCTTCCCCAATATCGTTTACTCATTTATCATCGCTCTAAAGCGGCCGAATAACCACACACAAATCGTAGTTTACGAAATCAATAGAACGCGCACAAGACACCAGAAGACTTGCGAATTCACAATTGGCTACATGGCGCAGCACCTGCAGATTCTGTCCGACATGCGATTGGTTGTGGCTCACCAAAGCGGATTTACCGCATACTTTCTGCGCGGAGAAGCAACTGCAATGT
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0023081-'5-4,'5-3,6-4=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.251 A=0.000 C2=0.000
Domain overlap (PFAM):
C1:
PF0006920=Pkinase=PD(72.2=20.1),PF0043319=Pkinase_C=WD(100=5.0),PF088265=DMPK_coil=WD(100=6.2),PF0013017=C1_1=WD(100=5.5)
A:
PF0078017=CNH=PU(9.3=28.0)
C2:
PF0078017=CNH=FE(51.3=100)
Main Inclusion Isoform:
FBpp0072194

Main Skipping Isoform:
NA
Other Inclusion Isoforms:
NA
Other Skipping Isoforms:
NA
Associated events
Conservation
Primers PCR
Suggestions for RT-PCR validation
F:
CCAAGTCGGGGGTGATTAAGC
R:
GCTTTCCGCAGAGAATGACGA
Band lengths:
305-582
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)