Special

DmeEX0004835 @ dm6

Exon Skipping

Gene
FBgn0010051 | Itp-r83A
Description
The gene Inositol 1,4,5,-trisphosphate receptor is referred to in FlyBase by the symbol DmelItpr (CG1063, FBgn0010051). It is a protein_coding_gene from Dmel. It has 4 annotated transcripts and 4 polypeptides (2 unique). Gene sequence location is 3R:5517117..5539411. Its molecular function is described by: calcium ion binding; phosphatidylinositol binding; inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; inositol 1,4,5 trisphosphate binding. It is involved in the biological process described with 22 unique terms, many of which group under: behavior; response to nutrient levels; response to starvation; sensory perception; regulation of feeding behavior. 52 alleles are reported. The phenotypes of these alleles manifest in: plasma membrane bounded cell projection; alimentary canal; cellular anatomical entity; developing material anatomical entity; organelle. The phenotypic classes of alleles include: phenotype; increased mortality; size defective; body size defective. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 12-18 embryonic stages.
Coordinates
chr3R:5536714-5537325:+
Coord C1 exon
chr3R:5536714-5536906
Coord A exon
chr3R:5536971-5537093
Coord C2 exon
chr3R:5537153-5537325
Length
123 bp
Sequences
Splice sites
3' ss Seq
TGATCTTTGTAAATGCATAGGTC
3' ss Score
5.6
5' ss Seq
CAGGTGAGA
5' ss Score
9.22
Exon sequences
Seq C1 exon
ATTGTTCGAAACGATCGCACTCTAGAGCAGATAGTCTTTCCCATTCCCGAGATCTGTGAATACCTGACCACGGACACCAAAATCAAAATCCTCAACACCGCAGAACGGGACGACCAAGGATCCAAAGTGGCGGACTTCTTTGACAAGGCAGAGGAAATGTTTAACGAAATGAAATGGCAAAAGAAGTTAAGAA
Seq A exon
GTCAACCCTTACTATTTTGGATAAGCAGTTACATGTCTCTTTGGAGCAACATCCTCTTTAACTGTGTTGTCGTTATCAATATGATTGTGGCCTTCTTCTATCCCTTTGATAATACTGTGCCAG
Seq C2 exon
AGCTCAGTTCCCATATCTCCTTGCTGTTCTGGATCATAACAATATTCTCACTTGTTATTGTGTTAGCGCTACCTCGGGAGTCTGGAATTAGAACCTTCATAGGCTCCGTCATCCTTCGATTCATCTTTTTACTAGGGCCGGAGTCTACTCTCTGCTTACTGGGAGTCGTCACG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0010051-'24-19,'24-18,25-19
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact

Alternative protein isoforms (Ref)

No structure available
Features
Disorder rate (Iupred):
  C1=0.000 A=0.000 C2=0.000
Domain overlap (PFAM):

C1:
PF0052026=Ion_trans=PU(1.5=7.7)
A:
PF0052026=Ion_trans=FE(12.4=100)
C2:
PF0052026=Ion_trans=FE(17.2=100)


Main Inclusion Isoform:
FBpp0078335


Main Skipping Isoform:
NA


Other Inclusion Isoforms:
FBpp0078336, FBpp0310670


Other Skipping Isoforms:
NA
Associated events
Conservation
Chicken
(galGal4)
HIGH PSI
Chicken
(galGal3)
HIGH PSI
Zebrafish
(danRer10)
HIGH PSI
Zebrafish
(danRer10)
HIGH PSI
Zebrafish
(danRer10)
HIGH PSI
Primers PCR
Suggestions for RT-PCR validation
F:
ATACCTGACCACGGACACCAA
R:
GAATCGAAGGATGACGGAGCC
Band lengths:
256-379
Functional annotations
There are 0 annotated functions for this event


GENOMIC CONTEXT[edit]

INCLUSION PATTERN[edit]


SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)