DmeEX0003492 @ dm6

Exon Skipping

Gene

FBgn0020503 | CLIP-190

Description

The gene Cytoplasmic linker protein 190 is referred to in FlyBase by the symbol DmelCLIP-190 (CG5020, FBgn0020503). It is a protein_coding_gene from Dmel. It has 16 annotated transcripts and 16 polypeptides (15 unique). Gene sequence location is 2L:17384700..17409698. Its molecular function is described by: microtubule binding; myosin VI heavy chain binding; actin binding; protein binding; microtubule plus-end binding. It is involved in the biological process described with: nuclear migration; cytoplasmic microtubule organization; cellularization; establishment of mitotic spindle orientation. 21 alleles are reported. No phenotypic data is available. The phenotypic classes of alleles include: viable; fertile. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 18-24 hour embryonic stages, at stages throughout the pupal period, in adult male stages.

Coordinates

chr2L:17400893-17402485:+

Coord C1 exon

chr2L:17400893-17401058

Coord A exon

chr2L:17401113-17401290

Coord C2 exon

chr2L:17402375-17402485

Length

178 bp

Sequences

Splice sites

3' ss Seq

CTGATCCATCCCCATTGCAGATA

3' ss Score

9.94

5' ss Seq

CAGGTATAA

5' ss Score

7.46

Exon sequences

Seq C1 exon

AGAATGGAATGGCTGTGGGCGATCGTGTGATTGTCTCTTCTGGATTTGGTAGTCGTCCTGGTATCTTACGCTATTTGGGAGAGACACAGTTTGCTCCCGGCAACTGGTGCGGTGTGGAATTGGATGAGCCTAGCGGCAAAAACGATGGAACTGTCGATGATATCAG

Seq A exon

ATACTTTGAGTGCAAGCCCAAGTACGGGGTGTTTGTACCTATTGCGAAGGTTTCACTGTCGCCGTCGTCCAAGAAAACGCGTCTTTCCAGGACCGGATCAAGGGAGTCGCTCACCTCGATTGGCACCATGAACAGCATCGCCACCACGGCCACGTCGCGCATGCGCATGAATGCTCAG

Seq C2 exon

GATCTGCTGCGCGAGAAGCAACAACATGTGGAGAAGCTGATGGTGGAGCGCGACCTGGACCGCGAGGATGCCCAGAACCAGGCGCTGCAGCTGCAGAAGAACATCAACGAG

VastDB Features

Vast-tools module Information

Secondary ID

FBgn0020503_MULTIEX1-8/10=7-10

Average complexity

C2

Mappability confidence:

100%=100=100%

Protein Impact

ORF disruption upon sequence exclusion

No structure available

Features

Disorder rate (Iupred):

C1=0.179 A=0.549 C2=0.589

Domain overlap (PFAM):

C1:

PF0130220=CAP_GLY=PU(72.5=89.3)

A:

PF0130220=CAP_GLY=PD(26.1=30.0)

C2:

NO

Main Inclusion Isoform:

FBpp0304726

Main Skipping Isoform:

NA

Other Inclusion Isoforms:

FBpp0080528, FBpp0080529, FBpp0080530, FBpp0288701, FBpp0288702, FBpp0290655, FBpp0290656, FBpp0290657, FBpp0304724, FBpp0304725, FBpp0304727, FBpp0304728, FBpp0308841

Other Skipping Isoforms:

NA

Associated events

Conservation

Human

(hg38)

chr12:122360959-122361181

ALTERNATIVE

HsaEX0015665

(CLIP1)

Human

(hg38)