DmeEX0009225 @ dm6
Exon Skipping
Gene
FBgn0261549 | rdgA
Description
The gene retinal degeneration A is referred to in FlyBase by the symbol Dmel
dgA (CG42667, FBgn0261549). It is a protein_coding_gene from Dmel. It has 12 annotated transcripts and 12 polypeptides (11 unique). Gene sequence location is X:8907068..9029476. Its molecular function is described by: diacylglycerol kinase activity; NAD+ kinase activity. It is involved in the biological process described with 14 unique terms, many of which group under: system process; nervous system process; multicellular organismal process; taxis; retina homeostasis. 67 alleles are reported. The phenotypes of these alleles manifest in: tergum; syncytium; plasma membrane bounded cell projection; Z disc; I band. The phenotypic classes of alleles include: flight defective; wild-type; increased mortality; phenotype. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed during late pupal stages.
Coordinates
chrX:9022018-9024418:+
Coord C1 exon
chrX:9022018-9022239
Coord A exon
chrX:9024074-9024137
Coord C2 exon
chrX:9024261-9024418
Length
64 bp
Sequences
Splice sites
3' ss Seq
CACATAAATATAAATAATAGCCC
3' ss Score
0.48
5' ss Seq
ATGGTAGCT
5' ss Score
2.12
Exon sequences
Seq C1 exon
CCTGCACCGCTGAGCACTACTTCCGGATCGATCGTGCCCAGGAGCATCTGCACTATATCTGCGACATTGCCATCGATGAACTGTATATCCTGGACCACGAGGCGGCCACCATGCCGCAGACACCCGATCAGGAGCGCTCCTTTGCAGCCTTCTCGCAGCGGCAGGCACAGAACGAGCGACGCCAAATGGATCAGGCCCAGGGTCGCGGCCCGGGCAGCACCG
Seq A exon
CCCTATACTGGAGCAAACTTCCGATGCCATACTACTAGCAGCCCAGAGCGGCGATCTCAATATG
Seq C2 exon
TTACGTGCACTACATGAACAAGGATACTCACTGCAGTCAGTGAACAAAAACGGACAGACGGCGCTGCATTTCGCCTGCAAATACAACCACAGGGACATTGTCAAATATATCATCGCAAGCGCCACACGACGCCTCATCAACATGGCCGACAAGGAGCT
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0261549_MULTIEX2-3/4=C1-4
Average complexity
C2
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.496 A=0.000 C2=0.012
Domain overlap (PFAM):
C1:
PF127962=Ank_2=PU(1.2=1.3)
A:
PF127962=Ank_2=FE(25.0=100)
C2:
PF127962=Ank_2=PD(51.2=81.1),PF127962=Ank_2=PU(19.2=28.3)
Main Inclusion Isoform:
FBpp0310580
Main Skipping Isoform:
FBpp0310579
Other Inclusion Isoforms:
FBpp0291800, FBpp0291801, FBpp0291802, FBpp0291803, FBpp0291804, FBpp0291805, FBpp0305778, FBpp0305779
Other Skipping Isoforms:
NA
Associated events
Conservation
Primers PCR
Suggestions for RT-PCR validation
F:
GAGCGACGCCAAATGGATCAG
R:
TGTGGTTGTATTTGCAGGCGA
Band lengths:
140-204
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)