DmeEX6011565 @ dm6

Exon Skipping

Gene

Description

The gene muscleblind is referred to in FlyBase by the symbol Dmelmbl (CG33197, FBgn0265487). It is a protein_coding_gene from Dmel. It has 19 annotated transcripts and 19 polypeptides (18 unique). Gene sequence location is 2R:17216549..17379376. Its molecular function is described by: RNA binding; metal ion binding; nucleic acid binding. It is involved in the biological process described with 9 unique terms, many of which group under: regulation of nucleobase-containing compound metabolic process; reproductive process; programmed cell death; apoptotic process; organic cyclic compound metabolic process. 93 alleles are reported. The phenotypes of these alleles manifest in: fascicle; larva; rhabdomere; visceral muscle; cytoskeleton. The phenotypic classes of alleles include: increased mortality during development; some die during embryonic stage; phenotype; courtship behavior defective.

Coordinates

chr2R:17351094-17354412:+

Coord C1 exon

chr2R:17351094-17351264

Coord A exon

chr2R:17352129-17352305

Coord C2 exon

chr2R:17354179-17354412

Length

177 bp

Sequences

Splice sites

3' ss Seq

GACCGACTATTCCCTTGCAGGCA

3' ss Score

9.35

5' ss Seq

GAGGTGAGT

5' ss Score

10.03

Exon sequences

Seq C1 exon

GGCCGCTGTAATCGTGATAAACCGCCGTGCAAATACTTTCATCCACCACAGCATCTGAAGGATCAGTTATTGATAAATGGACGCAATCATTTGGCCCTCAAGAATGCACTGATGCAACAGATGGGCATCGCGCCCGGCCAACCGGTCATATCGGGCCAAGTGCCAGCCGTG

Seq A exon

GCAACAAACCCCTATCTGACCGGCATTCCGGCCAACTCGTACAGTCCGTACTACACAACGGGACACCTGGTGCCCGCCTTGCTGGGTCCGGATCCCGTGACCTCCCAACTGGGACCCGTGGTGCCCCAAACAGTGCAGGTGGCACAGCAGAAAATACCACGTTCCGACAGATTAGAG

Seq C2 exon

GTGTGCCGCGAATTCCTGCGCGGCGCCTGCAAACGGGCGGAATCCGAGTGCCGGTTCGCCCATCCGCAGGAGAGCGTCGCCAGGCACGACGACGGCTCGATAACGGTTTGCATGGACGCCGTGAAGGGCAGGTGCGCACGCGACCCCTGCCGCTACTTCCATCCCCCCCTGCACCTACAGGCACAATTAAAAGCGGCCCAAACACGCGCCACCGCTGTCGCTGCTGCAGCTGCG

VastDB Features

Vast-tools module Information

Secondary ID

FBgn0265487-'17-20,'17-19,18-20=AN

Average complexity

A_C3

Mappability confidence:

100%=100=100%

Protein Impact

Alternative protein isoforms (Ref)

No structure available

Features

Disorder rate (disopred):

C1=0.286 A=0.435 C2=0.109

Domain overlap (PFAM):

C1:

NO

A:

PF0064219=zf-CCCH=PU(11.1=5.1)

C2:

PF0064219=zf-CCCH=PD(81.5=28.2)

Main Inclusion Isoform:

FBpp0307871

Main Skipping Isoform:

NA

Other Inclusion Isoforms:

FBpp0086143, FBpp0086144, FBpp0086146, FBpp0297556, FBpp0297558, FBpp0297559, FBpp0297561, FBpp0301759, FBpp0301760, FBpp0302029, FBpp0307872, FBpp0307873

Other Skipping Isoforms:

NA

Associated events

Conservation

Human

(hg38)

chr13:97343016-97343216

HIGH PSI

HsaEX6040782

(MBNL2)

Human

(hg38)