DmeEX6015932 @ dm6
Exon Skipping
Gene
FBgn0036059 | nudE
Description
The gene nudE is referred to in FlyBase by the symbol Dmel
udE (CG8104, FBgn0036059). It is a protein_coding_gene from Dmel. It has 6 annotated transcripts and 6 polypeptides (4 unique). Gene sequence location is 3L:9899241..9903031. Its molecular function is described by: microtubule binding. It is involved in the biological process described with 20 unique terms, many of which group under: organelle fission; anatomical structure formation involved in morphogenesis; regulation of microtubule motor activity; spindle localization; regulation of nervous system development. 19 alleles are reported. The phenotypes of these alleles manifest in: cellular anatomical entity; microtubule cytoskeleton; neuron projection; intracellular organelle; cell projection. The phenotypic classes of alleles include: lethal; viable; neuroanatomy defective; mitotic cell cycle defective; visible; body color defective. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes.
Coordinates
chr3L:9900423-9901434:+
Coord C1 exon
chr3L:9900423-9900696
Coord A exon
chr3L:9900761-9901018
Coord C2 exon
chr3L:9901343-9901434
Length
258 bp
Sequences
Splice sites
3' ss Seq
ATTCATCAAATCTATTGCAGATC
3' ss Score
8.38
5' ss Seq
AGAGTAAGA
5' ss Score
5.73
Exon sequences
Seq C1 exon
CTCAAGTTGGAATCGCATGGCATCGATATGTCAAACATGGAGAAACAGCTGGAAACGGTGAAGAAGGATCGCGACACCATGAAGGTGTACCTGCGGCAGCTGGAGCAGAAAAACGACGATTTGGAACGTGCCCATCGCATACTTAACGAAAGCATAGAGAATTTCGAGAAGATGCTGGATCAGGCCTACGAGAAGAACGCCCTTCTGGAGCTGGAAGTGGATGAAAAGGGATTGCTGCAGGAAAAACTACAGCGATTAATGGATGAGACGAGAG
Seq A exon
ATCTCAAACAAGAGCTGAACGTCAAGTCACGCTTTACCCCAGTGGTCAATGGAACGAGCGTTCCCACGGCAAACGACACAAATACGGTCAACAGCTCGATGAACTCGTCCGCCTCGCTGCCAAATGGTATTGTTGCCAATGGCGAATTGGTAAAACACGACAATGCTGTCGCCACAAGAGCCACCAGCGTCAGCGTCAACGCCCTCAATGGCAGTTTAGTTAATAGAAACGAATATAACCAGCAGCATTCGCTTAAGA
Seq C2 exon
ATCCCGAGAATCAAATCAATGGCAATTCCATGAACCCCAGCTCCCGCACAACGGCGCTCAACATTGTGGCCGACATGTTAAGAAAACTAAAC
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0036059-'7-8,'7-7,9-8=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.332 A=0.804 C2=0.790
Domain overlap (PFAM):
C1:
PF048808=NUDE_C=PU(31.8=44.6)
A:
PF048808=NUDE_C=FE(66.7=100)
C2:
PF048808=NUDE_C=PD(12.3=58.1)
Main Inclusion Isoform:
FBpp0112072

Main Skipping Isoform:
NA
Other Inclusion Isoforms:
FBpp0076073, FBpp0112071, FBpp0113092, FBpp0311743, FBpp0311744
Other Skipping Isoforms:
NA
Associated events
Conservation
Primers PCR
Suggestions for RT-PCR validation
F:
AAGAAGGATCGCGACACCATG
R:
ACATGTCGGCCACAATGTTGA
Band lengths:
292-550
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)