Special

DmeEX0005041 @ dm6

Exon Skipping

Gene
FBgn0027951 | MTA1-like
Description
The gene Metastasis associated 1-like is referred to in FlyBase by the symbol DmelMTA1-like (CG2244, FBgn0027951). It is a protein_coding_gene from Dmel. It has 5 annotated transcripts and 5 polypeptides (4 unique). Gene sequence location is 3R:5638655..5648738. Its molecular function is described by 7 unique terms, many of which group under: binding; transcription coregulator activity; transcription regulator activity; protein binding; transcription corepressor activity. It is involved in the biological process described with: chromosome condensation; negative regulation of transcription by RNA polymerase II; heterochromatin organization involved in chromatin silencing; histone deacetylation. 17 alleles are reported. The phenotypes of these alleles manifest in: oocyte; chromosome; region; segmental subdivision of integument; cell. The phenotypic classes of alleles include: visible; partially lethal; lethal; viable; suppressor of variegation; fertile. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages.
Coordinates
chr3R:5643449-5647215:-
Coord C1 exon
chr3R:5647054-5647215
Coord A exon
chr3R:5644163-5644270
Coord C2 exon
chr3R:5643449-5643777
Length
108 bp
Sequences
Splice sites
3' ss Seq
AAAATAACGCATCGCATCAGTGG
3' ss Score
-0.55
5' ss Seq
TAGGTACCA
5' ss Score
3.96
Exon sequences
Seq C1 exon
ACTATGTTTACGTTGAGACAACGCCGAACAGTCCCTACTTAATACGACGCATCGAGGAGCTGAACAAAAACCAAACCGGCAATGTGGAAGCGAAGGTCATGTGCTTCTACCGCCGCCGGGATCTGCCCAATCCGCTCGTGCAATTGGCCGACAAACACCAAC
Seq A exon
TGGCCACCGCCGAGGACTCACCGTTGGCGACCAAGCTGAAGAAGACCTGGCTCCGCACACCCGTAAGCGAGGAGCAGGCGGCGCAGGCTGTGCTCGATCCCTCAATAG
Seq C2 exon
CTGCCCTGGATGAGGAGCGCACCAGTCCAACGCAAACGTCTGGCGGAGGAGGCTCAGCCACCGGGAACTCCGGCAGCAACAGCAGCGGCACTTCCAACAACAACAGCAGCAGCACTGCCATCGGAGGTGGAGCGGGAGGCTCCGGAGGTGCAGGAGGCGACGCGGAGAAGGGCGAAGCGTTGACCAGCAAGCAGCGCTATCAGATCAAGCACCGCGAGCTATTTCTGTCACGCCAAGTCGAGTCGATACCCGCCACACAGATCCGAGGCAAGTGCTCGGTGACCCTGCTCAACGAGACGGAGTCCCTGCAGAGCTATCTTAATAAAGAC
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0027951_CASSETTE1
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact

Alternative protein isoforms (Ref)

No structure available
Features
Disorder rate (disopred):
  C1=0.102 A=0.986 C2=0.607
Domain overlap (PFAM):

C1:
PF0142613=BAH=PU(93.7=80.8)
A:
PF0142613=BAH=PD(9.0=16.2)
C2:
PF0142613=BAH=PD(4.7=2.7),PF0142613=BAH=PU(72.0=49.1)


Main Inclusion Isoform:
FBpp0303347


Main Skipping Isoform:
FBpp0288645


Other Inclusion Isoforms:
FBpp0078382


Other Skipping Isoforms:
FBpp0078383
Associated events
Primers PCR
Suggestions for RT-PCR validation
F:
ACGCCGAACAGTCCCTACTTA
R:
GCTGTTGTTGTTGGAAGTGCC
Band lengths:
249-357
Functional annotations
There are 0 annotated functions for this event


GENOMIC CONTEXT[edit]

INCLUSION PATTERN[edit]


SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)