DmeEX0006042 @ dm6
Exon Skipping
Gene
FBgn0026376 | Rgl
Description
The gene Ral guanine nucleotide dissociation stimulator-like is referred to in FlyBase by the symbol DmelRgl (CG8865, FBgn0026376). It is a protein_coding_gene from Dmel. It has 6 annotated transcripts and 6 polypeptides (3 unique). Gene sequence location is 3L:13906897..13925335. Its molecular function is described by: Ral guanyl-nucleotide exchange factor activity; Ras GTPase binding. It is involved in the biological process described with: regulation of Ras protein signal transduction; small GTPase mediated signal transduction; activation of GTPase activity. 31 alleles are reported. The phenotypes of these alleles manifest in: external compound sense organ; anatomical group; nervous system; somatic cell; mechanosensory system. The phenotypic classes of alleles include: visible; lethal; viable; fertile. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed during late pupal stages.
Coordinates
chr3L:13909832-13914525:-
Coord C1 exon
chr3L:13913962-13914525
Coord A exon
chr3L:13910484-13910585
Coord C2 exon
chr3L:13909832-13910215
Length
102 bp
Sequences
Splice sites
3' ss Seq
CCTTTTTCATTACCTTGCAGCCC
3' ss Score
10.12
5' ss Seq
AATGTGAGT
5' ss Score
7.8
Exon sequences
Seq C1 exon
TGATCAAGAGTCACACCTGCGCCTATCAGCTGCAGGATCTGACAGGATATAATCGCGCCCTGATGCCTCCGCTGGATAACACGGACTTTAGCAATGCCTGGCGGCAGGTGAACAACAACACCACCAGCCAATCCTGCGCCTACCACCAGCAGCGGCAGCAGCAGCAGCAGCAGCAGGATGCAAAGGATTCCAAGAGGCACTATCACCATCACACCTGTCCAAGACAGCGGAAAAAGTCCATGACCCCGGTGGAGCCAACGCATTTGTGTCAAAAGCACCAGGAAGCCAAGCAGCGGCGATCTAGATCCGCATCTGCCAAGCCGCGCAGGAACAGTTCGTATCACTCCTATGACGACTTGGATGTCTCATCCGCGGTACTCAATGCGGAGCGAAAGGTGGTGGCCAGTTTAAAGTATCTATGCGCCTGCACGGGAGCCACTTTGAGGAATCTCTCCAAGAAAACCAAGGATCTGCATGCCAAAAACTATACCTACACGAAG
Seq A exon
CCCACGTGGCGCCTTTGGGGCGAAGAGCACGAGAAGAATGCAATTTTCACCGTTTACCTGAAGAAAGTGCGATACCACCGACCGACGCCCACAGCCAGCAAT
Seq C2 exon
GACTCAGATGATGAGATTTCCCATCTGGAGTGGGAGACTGTACGCGTGCGTTTCGTTAAGGCGGCTACATTGGCTCGATTGGTGGAGGCGTTAGCCACCGACGACGGCGAGCTGGAGTCCACCTTCATCAACGTGTTCCTGTCCACATATCGCACCTTCTCCACACCCAAGCAGGTGCTCAGTCTGCTGACGCAACGGTACGATGCTCTGCATGAGAAGCACCTGGAGGAGTTGGAGCAGGCACAGCAAAATGGACAGGTCATGGATCCCGCCTACGATCCACACGCCTCCATTCACGAGCAGCACAAGAAAACCCTAGTCTCAGCGCTGCACGTCTGGCTGGATGGATTCCCGGAGGATTGGCACGAGGATAACCTGCAACAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0026376-'5-6,'5-5,6-6
Average complexity
C2
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.622 A=0.188 C2=0.227
Domain overlap (PFAM):
C1:
NO
A:
NO
C2:
PF0061815=RasGEF_N=PU(95.7=85.9)
Main Inclusion Isoform:
FBpp0303219
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
FBpp0075535, FBpp0075536, FBpp0075537, FBpp0075538
Other Skipping Isoforms:
NA
Associated events
Conservation
Chicken
(galGal3)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
GCGCAGGAACAGTTCGTATCA
R:
AGCCAATGTAGCCGCCTTAAC
Band lengths:
253-355
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)