DmeEX6002503 @ dm6
Exon Skipping
Gene
FBgn0040285 | Scamp
Description
The gene Scamp is referred to in FlyBase by the symbol DmelScamp (CG9195, FBgn0040285). It is a protein_coding_gene from Dmel. It has 4 annotated transcripts and 4 polypeptides (2 unique). Gene sequence location is X:15446179..15449883. Its molecular function is unknown. It is involved in the biological process described with: neuromuscular synaptic transmission; synaptic vesicle exocytosis; protein transport; long-term memory. 9 alleles are reported. No phenotypic data is available. The phenotypic classes of alleles include: viable; locomotor behavior defective; memory defective; heat stress response defective; short lived; fertile. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during early pupal stages.
Coordinates
chrX:15448379-15449883:-
Coord C1 exon
chrX:15449705-15449883
Coord A exon
chrX:15449281-15449508
Coord C2 exon
chrX:15448379-15448580
Length
228 bp
Sequences
Splice sites
3' ss Seq
TTCCCGGTTTTCCCCCGCAGGAC
3' ss Score
12.73
5' ss Seq
CAGGTAACC
5' ss Score
8.66
Exon sequences
Seq C1 exon
AAAACCGACATCGATAACTGAGCAGAGTCTTAGGGAAAATATACACAGCGAAAAGCAAAGTGCGAGTCAGTGCGTTTTTCTGGTCATTGAACAGCCGTATCCAAAGTAGAATTCCCATGTCCGGCTCCGGTCTCGACGAGAATCCCTTCGGGGAGCCCAATCTGGACAATCCGTTTGCG
Seq A exon
GACCCCGCCATCCAGCAGGCACGACGACTCCAGAGCGGCGCCGCCCTTGTCTCTCTTGAGGATTACAATCCATTCGAGGAGCAGGCCAAGCCGCAGCTGCAGATCAACTCAACGAACACGGCGGCGGTGGTCCAGCCGCTATCGCAGAACATTCCGCCCCCGCAGACCAGTTCCCTGGGCGCCTCGGCGCCTAGCACCAGCATACAGATCACCTCGGAGGAGCTGCAG
Seq C2 exon
CGCCGGCAGGAGGAGTTGGACCGCAAGGCCGCCGAACTGGACCGCCGCGAGCAGCAGCTACAGGGCAATGTGCCGCAGCTGAACAACTGGCCACCGCTGCCGGATAACTTTTGTGTAAAGCCGTGCTTCTACCAGGACTTCGAGGTGGAGATACCGCCCGAGTTCCAGAAACTGGTCAAGCGATTGTATTACATTTGGATTT
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0040285-'1-1,'1-0,5-1=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=1.000 A=0.898 C2=0.309
Domain overlap (PFAM):
C1:
NO
A:
PF039389=OmpH=PU(43.4=77.6),PF111013=DUF2884=PU(29.2=18.4),PF120723=DUF3552=PU(29.5=17.1)
C2:
PF039389=OmpH=FE(49.3=100),PF111013=DUF2884=PD(66.7=47.1),PF120723=DUF3552=PD(65.9=42.6),PF041448=SCAMP=PU(23.3=61.8)
Main Inclusion Isoform:
FBpp0073895
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
FBpp0304842, FBpp0304843
Other Skipping Isoforms:
NA
Associated events
Conservation
Primers PCR
Suggestions for RT-PCR validation
F:
AGTGCGAGTCAGTGCGTTTTT
R:
TTTCTGGAACTCGGGCGGTAT
Band lengths:
292-520
Functional annotations
There are 1 annotated functions for this event
PMID: 19158374
Encodes an experimentally validated Eukaryotic Linear Motif (ELM). Method: mutation analysis, surface plasmon resonance. ELM ID: ELMI001334; ELM sequence: PPSAPS; Overlap: FULL
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)