DmeEX6005399 @ dm6
Exon Skipping
Gene
FBgn0259111 | Ndae1
Description
The gene Na[+]-driven anion exchanger 1 is referred to in FlyBase by the symbol DmelNdae1 (CG42253, FBgn0259111). It is a protein_coding_gene from Dmel. It has 11 annotated transcripts and 11 polypeptides (10 unique). Gene sequence location is 2L:7223328..7249343. Its molecular function is described by: inorganic anion exchanger activity; anion:anion antiporter activity; sodium:bicarbonate symporter activity. It is involved in the biological process described with 6 unique terms, many of which group under: transport; establishment of localization; ion transmembrane transport; localization; inorganic ion transmembrane transport. 16 alleles are reported. The phenotype of these alleles manifest in: imaginal disc. The phenotypic classes of alleles include: viable; lethal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 18-24 hour embryonic stages.
Coordinates
chr2L:7236145-7240503:-
Coord C1 exon
chr2L:7240182-7240503
Coord A exon
chr2L:7237687-7237790
Coord C2 exon
chr2L:7236145-7236351
Length
104 bp
Sequences
Splice sites
3' ss Seq
AATGCCACTCTTCTTTTCAGACC
3' ss Score
8.23
5' ss Seq
AGGGTGAGT
5' ss Score
9.25
Exon sequences
Seq C1 exon
CAAAGTTAGTTAGTCTGCAATCGCCGGGACTCGCAGTCGAGTCGTCGGATCGCGTTTTTCAACCGAATTCGAAAAGTACAAATTCTAGCGATCCGAAAATCCAAACGATTAAAATCCAATAATAAAACGGAACAACACGTTCGCTTTTTATTGTGTCCACACTATTTTTACGCTATCAATTTGCTTTTTCGGCTGATAATCGCGAGGTGCGTGTGTGAAATTTTCGTGCAAACGGGCAAAAAAAAAAAAATATAACTCCAGTTCTTCGATCGCTATTTTGTGGCGATAAGGTGATGGCCGAAAAGAATGAGTACATCGAATT
Seq A exon
ACCTTGGACCATGAACTCCTCCAGCGGCGATGACGAGGCGCCGAAGGATCCGCGCACTGGCGGCGAGGATTTTACGCAACAATTTACAGAGAATGATTTCGAGG
Seq C2 exon
GACATCGGGCCCACACCGTTTATGTGGGCGTCCATGTGCCAGGAGGACGACGCCACTCGCAGCGCCGCCGCAAGCATCACCACAGTGGCCCCGGAGGTGGTGGCGGTGGCGGAGGTGGAGGCGGCTCCATCGGCGGATCCGGAAGTGTGGGCGGTGGTGCGGGCAAGGACAACGTCAGCGAGAAGCAACAGGAAGTGGAGCGACCAG
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0259111-'7-8,'7-5,11-8=AN
Average complexity
A_C2
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.657 A=0.972 C2=1.000
Domain overlap (PFAM):
C1:
NO
A:
NO
C2:
NO
Main Inclusion Isoform:
FBpp0288814
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
FBpp0288812, FBpp0288813, FBpp0304048, FBpp0304049, FBpp0304051, FBpp0304052, FBpp0304053, FBpp0304054
Other Skipping Isoforms:
NA
Associated events
Conservation
Human
(hg19)
No conservation detected
Mouse
(mm9)
No conservation detected
Primers PCR
Suggestions for RT-PCR validation
F:
TTGTGGCGATAAGGTGATGGC
R:
CACTTCCTGTTGCTTCTCGCT
Band lengths:
242-346
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)