Special

DmeEX6011757 @ dm6

Exon Skipping

Gene
Description
The gene Eag-like K[+] channel is referred to in FlyBase by the symbol DmelElk (CG5076, FBgn0011589). It is a protein_coding_gene from Dmel. It has 3 annotated transcripts and 3 polypeptides (2 unique). Gene sequence location is 2R:17873939..17926695. Its molecular function is described by: voltage-gated potassium channel activity; voltage-gated cation channel activity. It is involved in the biological process described with: regulation of membrane potential; potassium ion transmembrane transport; potassium ion transport. 15 alleles are reported. No phenotypic data is available. The phenotypic classes of alleles include: partially lethal - majority die; some die during pupal stage; viable. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult male stages.
Coordinates
chr2R:17901960-17907906:+
Coord C1 exon
chr2R:17901960-17902079
Coord A exon
chr2R:17903542-17903679
Coord C2 exon
chr2R:17907647-17907906
Length
138 bp
Sequences
Splice sites
3' ss Seq
AAAGCAAAAACACATTGCAGGTG
3' ss Score
1.1
5' ss Seq
GCGGTAAGT
5' ss Score
11.37
Exon sequences
Seq C1 exon
GCTGCTCATGTCATTTCCTTTACGGACCGGATACGAAGGAGGAGCACAAGCAGCAAATCGAGAAAAGTCTCTCCAATAAGATGGAACTGAAGCTGGAGGTTATTTTCTACAAGAAGGAAG
Seq A exon
GTGCCCCCTTCTGGTGTTTGTTCGACATTGTGCCCATCAAGAATGAGAAGCGCGATGTGGTGCTCTTTTTGGCATCCCACAAGGACATCACGCACACCAAGATGCTGGAGATGAATGTGAACGAGGAATGTGATAGCG
Seq C2 exon
TTTTTGCCCTTACAGCTGCCCTTTTGGGCGCCCGGTTCCGGGCCGGCTCCAATGCCGGAATGCTCGGCCTGGGCGGACTGCCCGGTCTGGGCGGACCGGCTGCCAGTGACGGGGATACGGAGGCGGGTGAGGGCAACAATCTGGACGTTCCCGCCGGCTGCAACATGGGTCGACGGCGCAGTCGAGCGGTTCTCTACCAGCTATCCGGGCACTACAAGCCGGAAAAGGGTGGCGTGAAGACCAAGTTGAAACTGGGCAAT
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0011589-'6-8,'6-6,7-8=AN
Average complexity
A_C2
Mappability confidence:
100%=100=100%
Protein Impact

Alternative protein isoforms (Ref)

No structure available
Features
Disorder rate (Iupred):
  C1=0.130 A=0.007 C2=0.224
Domain overlap (PFAM):

C1:
PF134261=PAS_9=FE(37.7=100)
A:
PF134261=PAS_9=PD(29.2=66.0)
C2:
NO


Main Inclusion Isoform:
FBpp0085981


Main Skipping Isoform:
NA


Other Inclusion Isoforms:
FBpp0309248


Other Skipping Isoforms:
NA
Associated events
Conservation
Primers PCR
Suggestions for RT-PCR validation
F:
AGATGGAACTGAAGCTGGAGGT
R:
GTAGTGCCCGGATAGCTGGTA
Band lengths:
257-395
Functional annotations
There are 0 annotated functions for this event


GENOMIC CONTEXT[edit]

INCLUSION PATTERN[edit]


SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)