Special

MmuEX0024725 @ mm10

Exon Skipping

Gene
ENSMUSG00000030102 | Itpr1
Description
inositol 1,4,5-trisphosphate receptor 1 [Source:MGI Symbol;Acc:MGI:96623]
Coordinates
chr6:108406090-108542064:+
Coord C1 exon
chr6:108406090-108406218
Coord A exon
chr6:108410809-108410929
Coord C2 exon
chr6:108541903-108542064
Length
121 bp
Sequences
Splice sites
3' ss Seq
CTCGCCTCTCTCTCTTATAGACC
3' ss Score
11.6
5' ss Seq
TAGGTAAGG
5' ss Score
9.31
Exon sequences
Seq C1 exon
GCCTGTAACAACACAAGCGACAGGAAGCACGCAGACTCCATTCTGGAGAAGTACGTCACTGAAATCGTGATGAGCATCGTCACCACCTTCTTCAGCTCTCCCTTCTCAGACCAGAGCACCACTCTGCAG
Seq A exon
ACCCGCCAGCCTGTCTTTGTGCAACTCCTGCAAGGCGTGTTCCGAGTTTACCACTGCAACTGGCTGATGCCGAGCCAAAAAGCCTCGGTGGAGAGCTGCATCCGGGTGCTCTCTGACGTAG
Seq C2 exon
GAAAGAAACCTTGATTGGTTCCCCAGAATGAGAGCCATGTCCCTGGTCAGCAGCGATTCTGAAGGGGAACAGAACGAGCTGAGGAACCTGCAGGAGAAGCTGGAGTCTACCATGAAGCTGGTCACCAATCTTTCTGGCCAGCTGTCAGAACTAAAGGACCAG
VastDB Features
Vast-tools module Information
Secondary ID
ENSMUSG00000030102_MULTIEX1-34/59=33-C2
Average complexity
C3
Mappability confidence:
97%=97=100%
Protein Impact





	

	
ORF disruption upon sequence exclusion





No structure available

		

			
Features


			

				
Disorder rate (Iupred):
  C1=0.000 A=0.000 C2=0.359
 
                        

				
Domain overlap (PFAM):

					





						

							
C1:
NO

							
A:
NO

							
C2:
NO

						

					

				








    
Main Inclusion Isoform:
ENSMUSP00000032192





     
                   









    
Main Skipping Isoform:
ENSMUST00000032192fB11678





     
      









    
Other Inclusion Isoforms:
ENSMUSP00000144880
          









    
Other Skipping Isoforms:
NA
  



Associated events







Other assemblies


mm9




Conservation


Human
(hg38)
chr3:4702830-4702946 
ALTERNATIVE
HsaEX0032552
(ITPR1)
Human
(hg19)
chr3:4744514-4744634 
HIGH PSI
HsaEX0032552
(ITPR1)
Rat
(rn6)
chr4:140443976-140444096 
HIGH PSI
RnoEX0045394
(Itpr1)
Cow
(bosTau6)
chr22:21753013-21753133 
HIGH PSI
BtaEX6093958
(ITPR1)
Chicken
(galGal4)
chr12:18460136-18460252 
HIGH PSI
GgaEX1030861
(ITPR1)
Chicken
(galGal3)
chr12:19103772-19103892 
HIGH PSI
GgaEX1030861
(Q9DEX2_CHICK)
Zebrafish
(danRer10)
chr11:35646898-35647018 
HIGH PSI
DreEX6092759
(itpr1b)
Fruitfly
(dm6)
No conservation detected




Primers PCR

	

		

			
Suggestions for RT-PCR validation

			

				
F: 
AAGCACGCAGACTCCATTCTG

				
R: 
AGCTGGCCAGAAAGATTGGTG

				
Band lengths: 
248-369

			

		

	





	
Functional annotations
(Submit an annotation)

	


There are 0 annotated functions for this event 


		










GENOMIC CONTEXT[edit]












INCLUSION PATTERN[edit]






SPECIAL DATASETS
  • Pre-implantation embryo development
  • Ribosome-engaged transcriptomes of neuronal types
  • Neural differentiation time course
  • Muscular differentiation time course
  • Spermatogenesis cell types
  • Reprogramming of fibroblasts to iPSCs
  • Hematopoietic precursors and cell types





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