DmeEX0009226 @ dm6
Exon Skipping
Gene
FBgn0261549 | rdgA
Description
The gene retinal degeneration A is referred to in FlyBase by the symbol Dmel
dgA (CG42667, FBgn0261549). It is a protein_coding_gene from Dmel. It has 12 annotated transcripts and 12 polypeptides (11 unique). Gene sequence location is X:8907068..9029476. Its molecular function is described by: diacylglycerol kinase activity; NAD+ kinase activity. It is involved in the biological process described with 14 unique terms, many of which group under: system process; nervous system process; multicellular organismal process; taxis; retina homeostasis. 67 alleles are reported. The phenotypes of these alleles manifest in: tergum; syncytium; plasma membrane bounded cell projection; Z disc; I band. The phenotypic classes of alleles include: flight defective; wild-type; increased mortality; phenotype. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed during late pupal stages.
Coordinates
chrX:9022018-9024936:+
Coord C1 exon
chrX:9022018-9022239
Coord A exon
chrX:9024261-9024418
Coord C2 exon
chrX:9024624-9024936
Length
158 bp
Sequences
Splice sites
3' ss Seq
ACCCCCCAATTTTTTTTCAGTTA
3' ss Score
8.98
5' ss Seq
GCTGTAAGT
5' ss Score
8.56
Exon sequences
Seq C1 exon
CCTGCACCGCTGAGCACTACTTCCGGATCGATCGTGCCCAGGAGCATCTGCACTATATCTGCGACATTGCCATCGATGAACTGTATATCCTGGACCACGAGGCGGCCACCATGCCGCAGACACCCGATCAGGAGCGCTCCTTTGCAGCCTTCTCGCAGCGGCAGGCACAGAACGAGCGACGCCAAATGGATCAGGCCCAGGGTCGCGGCCCGGGCAGCACCG
Seq A exon
TTACGTGCACTACATGAACAAGGATACTCACTGCAGTCAGTGAACAAAAACGGACAGACGGCGCTGCATTTCGCCTGCAAATACAACCACAGGGACATTGTCAAATATATCATCGCAAGCGCCACACGACGCCTCATCAACATGGCCGACAAGGAGCT
Seq C2 exon
TGGACAGACGGCGCTTCACATTGCCGCCGAGCAGAATCGCCGCGACATCTGCGTGATGCTGGTTGCCGCCGGCGCCCATTTGGATACCCTAGACTCCGGCGGAAATACGCCCATGATGGTGGCCTTCAACAAGAACGCCAACGAGATAGCCACCTATTTGGAAAGTAAGCAGGGGACTCAGCCCGTCGACGGCTGGCTCGACGACTAGACGAATCGACGATCATCTCACAAAATGCCGCAGTTCCCCGCCAAGTAGAGCAATCGCTAGACAAGCTTACTACTTATTCAACATTCAGACATTTAAATGAAAAAC
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0261549_MULTIEX2-4/4=C1-C2
Average complexity
C2
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (No Ref, Alt. Stop)
No structure available
Features
Disorder rate (Iupred):
C1=0.496 A=0.012 C2=0.086
Domain overlap (PFAM):
C1:
PF127962=Ank_2=PU(1.2=1.3)
A:
PF127962=Ank_2=PD(51.2=81.1),PF127962=Ank_2=PU(19.2=28.3)
C2:
PF127962=Ank_2=PD(79.5=88.6)
Main Inclusion Isoform:
FBpp0310579

Main Skipping Isoform:
FBpp0310580

Other Inclusion Isoforms:
FBpp0291800, FBpp0291801, FBpp0291802, FBpp0291803, FBpp0291804, FBpp0291805, FBpp0305778, FBpp0305779
Other Skipping Isoforms:
NA
Associated events
Conservation
Primers PCR
Suggestions for RT-PCR validation
F:
TGCGACATTGCCATCGATGAA
R:
CTAGGGTATCCAAATGGGCGC
Band lengths:
255-413
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)