Special

DmeEX6002643 @ dm6

Exon Skipping

Gene
Description
The gene shibire is referred to in FlyBase by the symbol Dmelshi (CG18102, FBgn0003392). It is a protein_coding_gene from Dmel. It has 16 annotated transcripts and 16 polypeptides (7 unique). Gene sequence location is X:15892116..15906716. Its molecular function is described by: GTP binding; actin binding; microtubule binding; GTPase activity. It is involved in the biological process described with 49 unique terms, many of which group under: mitotic cell cycle; synaptic signaling; organelle fission; cell motility; cell communication. 104 alleles are reported. The phenotypes of these alleles manifest in: cellular anatomical entity; apical plasma membrane; pacemaker neuron; cell division site; neuromuscular junction. The phenotypic classes of alleles include: behavior defective; sensory perception defective; phenotype; increased mortality. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes.
Coordinates
chrX:15892828-15895591:+
Coord C1 exon
chrX:15892828-15893150
Coord A exon
chrX:15894693-15894766
Coord C2 exon
chrX:15894835-15895591
Length
74 bp
Sequences
Splice sites
3' ss Seq
ACGTTTTCCCCATTTTACAGAGA
3' ss Score
9.28
5' ss Seq
CCGGTAAGT
5' ss Score
10.91
Exon sequences
Seq C1 exon
AGGAGTGTGTGCAGTGAAGTAAAGCCAGCGATTAAAGGAAACAGCATAGAAAAAAAAAAGACCCGGGAGCTGAGCAGTAAAAACACAAACATCCGGACGAGTTGGGATCGCAGTTCGATCTGATCTGATCTGATATCTAATCTAATCTAATTGTGAGGGAAATCGGACCTCGCCGCAATGGATAGTTTAATTACAATTGTTAACAAGCTGCAAGATGCGTTCACATCGCTCGGCGTCCACATGCAACTGGATCTGCCGCAGATCGCGGTGGTCGGTGGCCAGTCAGCTGGCAAGAGTTCCGTTTTGGAGAACTTTGTGGGCAA
Seq A exon
AGATTTCTTGCCGCGCGGCTCTGGTATCGTAACTCGGAGACCACTAATCTTGCAACTGATCAATGGAGTTACCG
Seq C2 exon
AATATGGCGAGTTCCTTCACATTAAAGGCAAGAAGTTTTCCAGCTTCGATGAGATCAGAAAAGAAATCGAAGATGAAACGGATCGTGTGACCGGTAGTAACAAAGGCATTTCAAACATTCCAATTAATTTGCGCGTCTACTCGCCGCACGTACTCAATTTAACCCTGATCGATTTGCCAGGCCTGACAAAGGTGGCCATTGGCGATCAACCGGTGGATATTGAGCAGCAAATTAAGCAGATGATATTCCAATTTATTCGCAAAGAGACTTGTTTAATTTTGGCTGTGACCCCGGCCAATACGGATCTGGCCAATTCGGATGCCCTCAAGCTGGCCAAGGAGGTGGATCCACAGGGTGTGCGAACCATTGGCGTTATAACCAAGCTGGATCTGATGGACGAGGGCACCGATGCACGCGACATTCTGGAGAATAAGCTGCTTCCGCTGCGACGTGGCTATATTGGCGTGGTGAATAGATCCCAAAAGGATATCGAGGGGCGC
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0003392-'15-6,'15-5,17-6=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact

ORF disruption upon sequence exclusion

No structure available
Features
Disorder rate (Iupred):
  C1=0.000 A=0.000 C2=0.040
Domain overlap (PFAM):

C1:
PF0035018=Dynamin_N=PU(11.5=40.8)
A:
PF0035018=Dynamin_N=FE(14.4=100)
C2:
PF0035018=Dynamin_N=PD(73.6=50.6),PF0103115=Dynamin_M=PU(39.0=45.5)


Main Inclusion Isoform:
FBpp0305866


Main Skipping Isoform:
FBtr0301597fB1068


Other Inclusion Isoforms:
FBpp0073928, FBpp0073929, FBpp0089277, FBpp0089278, FBpp0089279, FBpp0089280, FBpp0110335, FBpp0110336, FBpp0290809, FBpp0290810, FBpp0290811, FBpp0290812, FBpp0305867, FBpp0309359


Other Skipping Isoforms:
NA
Associated events
Conservation
Chicken
(galGal4)
HIGH PSI
Chicken
(galGal4)
HIGH PSI
Zebrafish
(danRer10)
HIGH PSI
Zebrafish
(danRer10)
HIGH PSI
Zebrafish
(danRer10)
HIGH PSI
Zebrafish
(danRer10)
HIGH PSI
Primers PCR
Suggestions for RT-PCR validation
F:
TCCACATGCAACTGGATCTGC
R:
CGGTCACACGATCCGTTTCAT
Band lengths:
181-255
Functional annotations
There are 0 annotated functions for this event


GENOMIC CONTEXT[edit]

INCLUSION PATTERN[edit]


SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)