DmeEX6011080 @ dm6
Exon Skipping
Gene
FBgn0264089 | sli
Description
The gene slit is referred to in FlyBase by the symbol Dmelsli (CG43758, FBgn0264089). It is a protein_coding_gene from Dmel. It has 7 annotated transcripts and 7 polypeptides (4 unique). Gene sequence location is 2R:15869495..15922118. Its molecular function is described by: Roundabout binding; heparin binding; calcium ion binding. It is involved in the biological process described with 21 unique terms, many of which group under: embryo development; positive regulation of cell motility; positive regulation of cell adhesion; positive regulation of response to external stimulus; exocrine system development. 79 alleles are reported. The phenotypes of these alleles manifest in: plasma membrane bounded cell projection; segmental subdivision of organ system; cell projection; larval multidendritic neuron; neuron projection. The phenotypic classes of alleles include: lethal - all die before end of prepupal stage; phenotype; cell shape defective; increased mortality during development.
Coordinates
chr2R:15879396-15880079:-
Coord C1 exon
chr2R:15879922-15880079
Coord A exon
chr2R:15879699-15879852
Coord C2 exon
chr2R:15879396-15879614
Length
154 bp
Sequences
Splice sites
3' ss Seq
CCCCCTCTTCCGCATTTCAGGCT
3' ss Score
10.13
5' ss Seq
GCTGTAAGT
5' ss Score
8.56
Exon sequences
Seq C1 exon
ACATCTGGCCAAGAATCCTTTCATCTGCGACTGCAATCTGCGCTGGCTGGCCGACTATTTGCACAAAAATCCCATAGAGACGAGTGGAGCCCGCTGCGAGTCACCGAAGCGGATGCATCGTCGTCGGATTGAATCGCTGCGCGAGGAGAAATTCAAAT
Seq A exon
GCTCCTGGGATGAATTGCGGATGAAGCTGTCCGGCGAGTGCCGCATGGACTCCGACTGTCCGGCCATGTGCCACTGCGAGGGCACCACCGTGGATTGCACGGGCCGGGGCCTGAAGGAGATTCCGCGCGACATTCCCCTGCACACAACTGAGCT
Seq C2 exon
TTTGCTCAACGACAACGAACTGGGACGCATCAGTTCCGATGGCCTCTTTGGTCGCCTGCCGCACTTGGTGAAGCTGGAATTGAAGCGCAACCAGCTGACCGGCATCGAGCCCAACGCCTTCGAGGGAGCATCCCACATCCAGGAGTTGCAGCTGGGCGAGAACAAGATCAAGGAGATATCGAACAAGATGTTCCTGGGACTGCACCAACTAAAAACGCT
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0264089-'13-13,'13-12,14-13=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact
ORF disruption upon sequence exclusion
No structure available
Features
Disorder rate (Iupred):
C1=0.037 A=0.000 C2=0.000
Domain overlap (PFAM):
C1:
NO
A:
PF0146213=LRRNT=WD(100=53.8),PF127992=LRR_4=PU(4.7=3.8)
C2:
PF127992=LRR_4=PD(93.0=54.1),PF138551=LRR_8=PU(47.5=39.2)
Main Inclusion Isoform:
FBpp0303578
Main Skipping Isoform:
NA
Other Inclusion Isoforms:
FBpp0303573, FBpp0303574, FBpp0303575, FBpp0303576, FBpp0303577
Other Skipping Isoforms:
NA
Associated events
Conservation
Primers PCR
Suggestions for RT-PCR validation
F:
GATGCATCGTCGTCGGATTGA
R:
TAGTTGGTGCAGTCCCAGGAA
Band lengths:
258-412
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)