Special

DmeEX0008050 @ dm6

Exon Skipping

Gene
Description
The gene genghis khan is referred to in FlyBase by the symbol Dmelgek (CG4012, FBgn0023081). It is a protein_coding_gene from Dmel. It has 2 annotated transcripts and 2 polypeptides (1 unique). Gene sequence location is 2R:24092079..24098636. Its molecular function is described by: protein kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding. It is involved in the biological process described with 6 unique terms, many of which group under: protein modification process; neuron differentiation; regulation of organelle organization; cell communication; nervous system development. 32 alleles are reported. The phenotypes of these alleles manifest in: neuron projection; cell projection; plasma membrane bounded cell projection; embryonic/larval cuticle; reproductive system. The phenotypic classes of alleles include: phenotype; increased mortality; increased mortality during development; semi-sterile. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the pupal period, in adult female stages.
Coordinates
chr2R:24092079-24092698:-
Coord C1 exon
chr2R:24092605-24092698
Coord A exon
chr2R:24092342-24092538
Coord C2 exon
chr2R:24092079-24092262
Length
197 bp
Sequences
Splice sites
3' ss Seq
TATTCGCTTTTTATTTGTAGTGA
3' ss Score
5.52
5' ss Seq
AAGGCAAGC
5' ss Score
2.46
Exon sequences
Seq C1 exon
AGGGCCTTTTGCAATACCGTGACGGAAATCGAAAGGGACTTCCGAGCATAAAGCGGAGATTCTCTATCAGGGAGATAAACAAGACCATCAAAAG
Seq A exon
TGATCGTAGATCAAAGATGATATCAGCACCGACTAATTTCAACCACATTTCTCACATGGGGCCAGGGGATGGCATTCAAAATCAACGACTCCTAGACTTACCAACCACGCTCGAAACAGCCGATCAAGCCTGCAGTCCAATAATACATTCGCTGAGTTGCATACCCCAGAGTAGAAAATCCAATTTTCTAGAACAAG
Seq C2 exon
TGGATGCAAACTCCGATGACTATGGCAATGACAACATTATCTCCAGAACGCCCAGTCCAATGGCATCGTCCTTCATGGACGGCTTAAGCAATAATGATTAACTTCAGTCAATCTCTACACGTGTAATTTAATCGATTTTTTAAGATAACTGTTTGTAATAAACATATTTAATTTCTCGAATATC
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0023081-'11-11,'11-8,12-11
Average complexity
S
Mappability confidence:
100%=100=100%
Protein Impact

Alternative protein isoforms (No Ref, Alt. Stop)

No structure available
Features
Disorder rate (Iupred):
  C1=0.000 A=0.403 C2=0.879
Domain overlap (PFAM):

C1:
NO
A:
PF0078623=PBD=WD(100=49.3)
C2:
NO


Main Inclusion Isoform:
FBpp0072194


Main Skipping Isoform:
NA


Other Inclusion Isoforms:
NA


Other Skipping Isoforms:
NA
Associated events
Conservation
Chicken
(galGal4)
ALTERNATIVE
Chicken
(galGal3)
ALTERNATIVE
Zebrafish
(danRer10)
Zebrafish
(danRer10)
Zebrafish
(danRer10)
ALTERNATIVE
Primers PCR
Suggestions for RT-PCR validation
F:
AGGGCCTTTTGCAATACCGTG
R:
ACACGTGTAGAGATTGACTGAAGT
Band lengths:
218-415
Functional annotations
There are 0 annotated functions for this event


GENOMIC CONTEXT[edit]

INCLUSION PATTERN[edit]


SPECIAL DATASETS

  • Neural diversity
  • Neurogenesis
  • Neuronal activity
  • Splicing factor regulation (brain)
  • Splicing factor regulation (SL2)