DmeEX6010970 @ dm6
Exon Skipping
Gene
FBgn0034013 | unc-5
Description
The gene unc-5 is referred to in FlyBase by the symbol Dmelunc-5 (CG8166, FBgn0034013). It is a protein_coding_gene from Dmel. It has 3 annotated transcripts and 3 polypeptides (1 unique). Gene sequence location is 2R:15340472..15368300. Its molecular function is described by: netrin receptor activity involved in chemorepulsion; netrin receptor activity. It is involved in the biological process described with 6 unique terms, many of which group under: multicellular organism development; anatomical structure morphogenesis; developmental process; regulation of locomotion; plasma membrane bounded cell projection morphogenesis. 29 alleles are reported. The phenotypes of these alleles manifest in: plasma membrane bounded cell projection; cell projection; dorsal vessel primordium; visual system neuron; filopodium. The phenotypic classes of alleles include: increased mortality; cell migration defective; phenotype; increased mortality during development. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 06-12 hour embryonic stages.
Coordinates
chr2R:15358009-15360468:+
Coord C1 exon
chr2R:15358009-15358290
Coord A exon
chr2R:15358579-15358749
Coord C2 exon
chr2R:15360415-15360468
Length
171 bp
Sequences
Splice sites
3' ss Seq
TTTCCGTTTTCATCCCACAGTCA
3' ss Score
10.4
5' ss Seq
CAGGTACGT
5' ss Score
10.65
Exon sequences
Seq C1 exon
ATATTCGCAAGTCCTTCAACCAGTCGCCCACCTCGCTGCGCCTGGAGCTGGGCAGTCGGGCGGAACTGCGCTGCGAACCACCCGGCGGTTTCCCCGAACCGAAGCTCACCTGGCACAAAAACAACGCGGTCATCACGGCGGACAGCGAGCCGGGGATCACCGTTTCGGCCGGCACACTCATCTTCCGCCAGGTGGCCCTGCAGCATATGGCCAACTATAGCTGCAGTGCGGAGAATATCGCTGGCAGACGCGTCTCCGATTCCGCCGTGCTCATCGTTTATG
Seq A exon
TCAACGGTGGCTGGAGCACCTGGAGTCCATGGCGCGAATGCAAGTGTGCGGGCAAGCCCAGCCAGGGAAGGAAGCGTTCGCGCACCTGCAACAATCCGATGCCATTGAATGGGGGCGCCCAGTGTCCGGGCCCCCAGATCCAGAAGTCCGCCGACTGCGCCGCATGTCCAG
Seq C2 exon
AGGACACTCAAATCGTGAGCCCTGATGGATTTGACATTTCGTCGAGTAAGCGCA
VastDB Features
Vast-tools module Information
Secondary ID
FBgn0034013-'10-8,'10-7,11-8=AN
Average complexity
A_S
Mappability confidence:
100%=100=100%
Protein Impact
Alternative protein isoforms (Ref)
No structure available
Features
Disorder rate (Iupred):
C1=0.053 A=0.172 C2=0.105
Domain overlap (PFAM):
C1:
PF0767911=I-set=WD(100=94.7)
A:
NO
C2:
NO
Main Inclusion Isoform:
FBpp0086514

Main Skipping Isoform:
NA
Other Inclusion Isoforms:
FBpp0309017
Other Skipping Isoforms:
NA
Associated events
Conservation
Primers PCR
Suggestions for RT-PCR validation
F:
GTTTCCCCGAACCGAAGCTC
R:
TGCGCTTACTCGACGAAATGT
Band lengths:
249-420
Functional annotations
There are 0 annotated functions for this event
GENOMIC CONTEXT[edit]
INCLUSION PATTERN[edit]
SPECIAL DATASETS
- Neural diversity
- Neurogenesis
- Neuronal activity
- Splicing factor regulation (brain)
- Splicing factor regulation (SL2)